Thrilled to share our latest work together with the labs of Yixiao Zhang and Charles Cox, featuring our own Ruitao Jin 金瑞涛 & Sitong published today in nature. Our part done at ANU Division of Biomedical Science & Biochemistry using supercomputing at NCI Australia #mechanosensation #biophysics nature.com/articles/s4158…

Congrats Charles Cox !! This is awesome

Happy to share the conformational ensemble of wild-type human TRPV3. For the first time the channel structure is open by applying agonists, 2-APB or THCV, without sensitizing mutations! Kirill Nadezhdin @arthurCantab Ira Talyzina science.org/doi/10.1126/sc…

Bellísimo.

No hay palabras que sirvan de consuelo en una noche de eliminación, pero Venezuela tiene que irse con la frente en alto. Líderes de grupo con paso perfecto, marcaron el mejor gol del torneo, protagonizaron el mejor juego del certamen y no perdieron ni una sola vez en 90 minutos.

Happy to hear that the 2024 Ion Channels GRS was a success! I was not able to make it since I am still waiting for my visa. Thankful for my amazing co-chair Anabel Fdez-Mariño, our mentors Henry Colecraft, Dr. Shivani Ahuja and Dr. George Kwabena Umanah, all the presenters, and sponsors

What a FANTASTIC Ion channels GRS! Gordon Research Conferences THANKS to all the attendees! You made the experience of chairing this conference GREAT. We miss my co-chair Luis O. Romero, but looking forward to the next one. Congrats to the new chairs Paula Bender & Roberta Castelli!

Work from Amanda Lewis and Marie Cronin now published Neuron. Piezo 1 ion channels can signal to other nearby membrane proteins just by changing their shape: doi.org/10.1016/j.neur…

I'm excited to share our serendipitous findings, now published in Nature, that reveal in high-resolution detail how sterols, PIP2, and PS are organized within the plasma membrane by a stretch-sensitive lattice of BAR-domain proteins. nature.com/articles/s4158…

Viva Venezuela 🇻🇪

We are a soliciting nominations for the 2025 Kenneth S. Cole Award given to one or more researchers in the field of membrane biophysics in acknowledgment of their exceptional research accomplishments, potential for future contributions, and service to the biophysics community.

What proteins surround PIEZO1 on the cell surface? We used a mass spec proteomic approach to capture a snapshot of the PIEZO1 interactome. One of these candidates, CADM1/SynCAM, slows the inactivation kinetics of PIEZO1 with little effect on PIEZO2. pnas.org/doi/10.1073/pn…

.Swetha Murthy deciphers mechanically activated ion channels at the single-channel level in dorsal root ganglion neurons. hubs.la/Q02RDwvy0 📒 In our #Neuroscience collection: hubs.la/Q02RDj-G0 #SfN24

It is finally out! Yes!!! Huge Thanks to Rob Gereau for the support and guidance. Congratulations to all the co-authors.

Very excited to see this work coming out. Combining membrane-active polymers with #proteomics we present the most optimal conditions to extract>2000 individual endogenous membrane proteins into nativenanodiscs Yale Cell Biology Yale West Campus Yale School of Medicine

Enhanced PIEZO1 Function Contributes to the Pathogenesis of Sickle Cell Disease biorxiv.org/content/10.110… #biorxiv_physio

PIEZO alert 🚨 Here, we uncovered how PIEZO1 contributes to the pathogenesis of sickle cell disease. I had a lot of fun measuring mechano-activated currents in the membrane of red blood cells. pnas.org/doi/10.1073/pn…

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

This October I’m drawing 1 molecule a day inspired by proteins in pdb rcsb pdb 💉🧬💻🔬💊🌱🧠🦠 #Inktober2025 Day 7 Prompt STARFISH Pdb: 6KG7 Starfish relies on sensory information. This is Piezo 2 - mechanically activated ion channel responsible for the sense of touch. Next: RECKLESS

PIEZO alert 🚨 Here, we show that cytoskeletal dysregulation contributes to impaired ion channel function that lead behavioral deficits, and that actin-binding proteins could serve as a target for enhancing motor coordination and spatial learning in AS. jneurosci.org/content/early/…