Structures of mammalian membrane proteins from a single cell culture dish! It is a great pleasure to share our latest collaborative work with the @RouslanEfremov lab biorxiv.org/content/10.110… #cryoEM #MembraneProteins #Microfluidics

This is the most important open source structural biology model release since AF3. Huge props to the Baker lab for open sourcing end-to-end antibody design github.com/RosettaCommons…

Amazing #cryoEM structures and incredible community here at CNIO Stop Cancer for the “machines acting on DNA and RNA” congress!

The ChimeraX 1.10 release candidate and daily builds can predict small complexes of proteins, nucleic acids and small molecules using Boltz on your Mac, Windows or Linux computer. rbvi.ucsf.edu/chimerax/data/…

🎉New preprint!🎉 Extremely excited to share CryoBoltz❄️⚡️, led by superstar Rishwanth Raghu! We develop a multiscale guidance recipe to steer structure prediction models (e.g. AlphaFold3 / Boltz-1) towards experimental cryo-EM density maps, including heterogeneous,

Building atomic models to cryo-EM maps of huge molecules is intimidating: crowded, uncertain copy numbers, variable resolution ... Fan Liu lab and team show how cross-linking MS can be used to build novel models of unknown complexes, like a giant virus❄️ ❄️biorxiv.org/content/10.110…

Researchers have developed a #DeepLearning system called BioEmu that rapidly generates diverse protein conformations, enabling fast, accurate insights into protein flexibility and function. Learn more this week in Science: scim.ag/41rCpxZ

New preprint - basically we noticed that by applying ab initio (SDG) at high res in CS, using a very small step size, we could crack some small proteins we hadn't been able to solve before. Read the preprint or head over to bluesky for a longer thread! biorxiv.org/content/10.110…

🔬 Fold proteomes privately, no queues, no bottlenecks Bring protein structure prediction to your desktop. Powered by the GB10 Grace Blackwell Superchip, our new NVIDIA DGX Spark will deliver: ⚡ 1 petaFLOP of AI performance 🧠 128 GB coherent unified system memory It’s more

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with Torben Heick Jensen’s lab we (Plaschka Lab and Julius Brennecke’s lab) discovered a direct mechanistic link between the export and decay machineries: biorxiv.org/content/10.110… (1/x)

Over the past week, Arc Institute published three new discoveries that I’m very proud of. • The world's first functional AI-generated genomes. Using Evo 2 (the largest biology ML model ever trained, which Arc released in partnership with NVIDIA in February), Arc scientists

Amazing open resource for diverse binder kinetics! We released a lot of our BindCraft binders that were not tested experimentally in the original study! Releasing consistent data like this will help the community to grow!