A new #CRISPR tool controlled by #miRNA go.nature.com/2H2HxQx Need more insights, read the comment go.nature.com/2ODsCy4

Essential gene networks in acute myeloid leukemia identified using a microRNA-knockout #CRISPR library screen. Gabra M [..] Salmena L. bioRxiv 2019-06-06 doi.org/10.1101/661140

More analysis of the impact of posting manuscripts to bioRxiv: biorxiv.org/content/10.110… (also love that this was also deposited as a pre-print, too!).

These simulations show how to flatten the coronavirus growth curve wapo.st/corona-simulat…

Reinfection could not occur in SARS-CoV-2 infected rhesus macaques | bioRxiv biorxiv.org/content/10.110…

Lead the way!!!

Golam Saffi, SalmenaLab et al. Pharm & Tox uncover a crucial signaling axis involving INPP4B, PIKfyve, and TRPML-1 that drives the peripheral localization of #lysosomes and lysosomal exocytosis to promote migratory and invasive properties of #PDAC cells. hubs.la/Q02KNvdL0

In Journal of Cell Biology, Saffi, SalmenaLab et al Pharm & Tox uncover a crucial signaling axis involving INPP4B, PIKfyve, & TRPML-1 that drives the peripheral localization of #lysosomes & lysosomal exocytosis to promote #migration & invasion of #PDAC cells. hubs.la/Q02KNtpm0

Heme is a fascinating molecule and regulates many properties of cancer cells. Here we uncovered a connection between heme biosynthesis and copper homeostasis among other pathways in AML. Check out our latest preprint Peter Mac Cancer Centre Peter Mac Research biorxiv.org/cgi/content/sh…

A University of Toronto research team led by Drs. Saffi, Botelho (@Botelho_Lab), and Salmena (SalmenaLab) demonstrated that INPP4B overexpression in #PDAC was associated with cancer progression. 📖 Read about their findings in Journal of Cell Biology. bit.ly/4dnNunE

Lenny Salmena SalmenaLab and I had the pleasure to co-host Lev Kats for a Blood and Stemness Group Princess Margaret Cancer Centre and Pharm & Tox joint seminar. We heard firsthand this fascinating story on the therapeutic potential of targeting heme biosynthesis in AML.

Phosphoinositide-focused CRISPR screen identifies novel genetic vulnerabilities in PDAC and AML cells biorxiv.org/cgi/content/sh… #biorxiv_cancer

U of T study uncovers new role for cell’s waste disposal system in spread of pancreatic cancer temertymedicine.utoronto.ca/news/u-t-study…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

Click link to learn more: globenewswire.com/news-release/2… SalmenaLab