Wonderful lab retreat in Brighton this year. Great discussions about the year ahead.

Extremely pleased to share our latest work (Krieg Lab and MurphyLab) on the ischemia-selective protection against cardiac ischemia/reperfusion (IR) injury by malonate, out now in Circulation Research. ahajournals.org/doi/10.1161/CI… (open access - so freely available!) 1/7

Malonate, a natural chemical in our bodies, helps to stop further damage following a heart attack. Our collaboration supporting @cambridge_uni and @mrc_mbu revealed how malonate enters damaged heart muscle, which could help to target future therapies. know.az/3RDC7wn

The transfer step in western blotting

Prag & colleagues demonstrate that #malonate selectively enters at risk tissue during #IR to block #SDH & cardiac damage. Learn more at ahajrnls.org/3REYa6c Hiran A. Prag Krieg Lab Dunja Aksentijevic Ricciarelli AstraZenecaUK Johannes Reinhold CambridgeCardio @MRCMBU

Merry Christmas from the TK-lab.

Delighted to present my research today at the Department of Medicine Research Day. Got the best poster award for it too! Krieg Lab Medicine at Cambridge

Have a read of Amin Mottahedin latest work on targeting succinate dehydrogenase in ischaemic stroke which I am pleased to be part of. It has some neat mass spec imaging as well! Krieg Lab MurphyLab sciencedirect.com/science/articl…

🚨To #immunometabolism and #mitochondria lovers everywhere🚨 There is an opportunity to join the newly minted Ryan group MRC MBU Cambridge University as a postdoctoral research associate. Please check out the advert below and I appreciate any shares⬇️⬇️⬇️ nature.com/naturecareers/…

We had a wonderful time and great science at our Mitochondrial Therapy Group MTG meeting at Caius College. MurphyLab Dylan Ryan Ana Vujic Kourosh Saeb-Parsy Dunja Aksentijevic Ricciarelli Hiran A. Prag Richard Hartley

Amazing news Ana Vujic, much deserved and can't wait to see the exciting research that the Vujic lab will produce.

Exciting news! I am recruiting, and looking for a talented Research Assistant. If you're passionate about heart failure and want to be part of an innovative and dynamic research team, I want to hear from you! Link: jobs.cam.ac.uk/job/41220/ Cambridge University, CambridgeCardio

Have a look at our recent review highlighting RET as a potential treatment against IR injury. ⁦Hiran A. Prag⁩ ⁦MurphyLab⁩ link.springer.com/article/10.100…

Jordan Jordan Lee presented our group with a nice e-poster at the European Stroke Org meeting in Basel. Great story of malonate protecting against ischemic stroke.

Have a look at our new story demonstrating chronic benefits against heart failure when malonate is given at reperfusion. MurphyLab Hiran A. Prag Ana Vujic

Our stroke research has been featured in this month’s British Heart Foundation newsletter. Check it out. comms.bhf.org.uk/cr/AQiXsA0Qm96…

🚨 New paper out from us, reveals a novel role for mitochondrial RET-ROS in #HFpEF. 🧬 ND6 mutation ➡️ 🫀 Hypertrophy 💔 Diastolic dysfunction 🏃‍♂️ ↓ Exercise capacity 💪 ↑ Lean mass 🍩 HFD worsened metabolism ✅ Exercise reversed many effects! doi.org/10.1152/ajphea…

Explore novel therapeutic opportunities in #stroke this #WorldStrokeDay Local arterial administration of acidified malonate as an adjunct therapy to thrombectomy may attenuate ischaemia–reperfusion injury &⬇️brain damage up to 60% academic.oup.com/cardiovascres/… #CardiovascularResearch