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#FriendOrFoe! DuPage, Castillo &co show Immunity that intratumoral injection of Listeria favors tumor growth by recruiting pro-tumoral neutrophils but it is protective if it recruits antitumoral CD8T cells formed during prior Listeria encounter! cell.com/immunity/abstr…

For the immunologists still on X science.org/doi/10.1126/sc…

mRNAs encoding adjuvant proteins boost immunity. A fantastic study from Hunter et al shows the value of IL12. Study validates original work on this concept, ref below. Kudos to the authors on this exciting discovery! ChrisHunter Penn Vet science.org/doi/10.1126/sc…

#WeekendRead! #ImmunometabolismPower! Wang, Fang &co show Nature Immunology that succiante is elevated in #IBD & exacerbates colitis by preventing succinylation of FOXP3, leading to its ubiquitination & degradation, impairing Treg cell functions & driving IL17! nature.com/articles/s4159…

Ivan Zanoni Nature Immunology In our setting, succinate has also been identified as pathogenic in the context of ulcerative colitis (UC). nature.com/articles/s4152…

#WeekendRead! #ToSuppressOrNotToSuppress! Van Der Veeken &co show Science Immunology that acute deletion of Foxp3 doesn’t alter Tregs under homeostasis but during inflammation continuous Foxp3 activity is necessary to actively suppress transcriptional programs science.org/doi/10.1126/sc…

Johnny Stine Ivan Zanoni ChrisHunter Penn Vet Not all PRR ligands are equal. Lot of work in this area these days.

#VitaminE_FriendOrFoe?! Javier Garcia-Bermudez &co show nature that tumors uptake lipoproteins rich in Vitamin E protecting cancer cells from ferroptosis! Identification of sulfated glycans as port of entry can be used therapeutically to force tumor cell death nature.com/articles/s4158…

What a fantastic day spent UW Department of Immunology! Lot of fun at my seminar, and amazing discussions about #interferons, host derived signals, #inflammasomes, inflammatory diseases, and the many different ways cells can die, and their consequences!

#WeekendRead! #BeyondPRRs! Witt, Russel Vance &co show nature that SP140 at the same time inhibits DNA viruses but also represses RESIST destabilizing interferon-b RNA, linking antiviral effector triggered immunity to multiple sclerosis & B cell tumors! nature.com/articles/s4158…

#WeekendRead! #BeyondNETosis! Carole Parent Lab &co show @NatCellBio that neutrophils can secrete nuclear-derived exosomes containing LTB4 & DNA which direct migration but also favor inflammation resolution via neutrophil retrotransmigration! go.nature.com/4e0d7vz

Our new prospective piece is out. Such a fun project Madison (Maddi) Strine, PhD Kerri St. Denis and Brett Vahkal. Yale Pediatrics Yale School of Medicine So much to learn about early life immunity

#LiveForever! Lei, Qu, Wang, Liu &co show Cell that boosting FOXO3 expression in mesenchymal progenitor cells & transferring them systemically reduces aging in macaques dampening chronic inflammation & enhancing cognitive & reproductive functions!dlvr.it/TLPTw2

Donne Miss this opportunity 👇👇👇

Just a Wednesday at the Burroughs Wellcome Fund Spring has sprung and there are -so- many flowers. Plant something new and grow it with a BWF PATH award. Letters of Intent are due July 17. If your lab is shifting into a higher gear, don’t talk yourself out of applying!

#NoTimeToDie! Dr. Sunny Shin Vasques &co show ASM journal that dendritic cells (#DCs) die upon encountering Legionella initially via caspase-11 dependent pyroptosis & later on by effector-triggered apoptosis, restricting Legionella replication! journals.asm.org/doi/10.1128/mb…

Our latest review on "Neuroimmune pathophysiology of long COVID" is out today! Amazing work of janna moen, phd is still masking 😷 and Christopher A. Baker 👏🏼👏🏼👏🏼 It is open-access; please share widely. #Neuroimmune #PAIS #LongCovid onlinelibrary.wiley.com/doi/10.1111/pc…

#WeekendRead! #ImmuneMechanosensing! Zhou &co show Cell Reports that rigid pathogenic candida hyphae are sensed by Piezo1 which upregulates Dectins via CREB/C/EBPb & drives antifungal NLRP3 activation via NDR1/2! cell.com/cell-reports/f…

#WeekendRead! #NoTimeToDie! Welcome to a new form of cell death: #efferoptosis! Poltorak, Muendlein &co show Science Immunology that during systemic inflammation TNF reprograms efferocytic macrophages to activate caspase-8 (not NLRP3!) pyrotosis & IL1b release science.org/doi/10.1126/sc…