Spatial Omics enthusiasts!! Spatial Proteomics is the Method of the Year 2024 🤩🤩🤩 nature.com/nmeth/volumes/…

The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳 For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread. nature.com/articles/s4159…

Exciting news - Spatial Proteomics is Nature Methods’ 2024 Method of the Year! Our commentary highlights how Deep Visual Proteomics (DVP) unites imaging, data science & high-res proteomics at single-cell resolution, fueling predictive tissue models and personalized medicine. Stay

After 4 fantastic years of research, with Na Cai & Matthias Heinig, I’m thrilled to share the first tissue specific map of apparent mtDNA heteroplasmy in humans and their relationships with donor age and mtDNA gene expression across 49 human tissues!👇 biorxiv.org/content/10.110…

Check out our nature review with Tiannan Guo Guomics and Judith Steen Judith Steen on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI nature.com/articles/s4158…

Happy to share our preprint in collaboration with the Lundberg Lab revealing spatial heterogeneity in human pancreatic islets with multiplexed Deep Visual Proteomics. Grateful for the fantastic team and collaboration!

A new publication in Cancer Cell uncovers how borderline ovarian tumors evolve into low-grade serous ovarian cancer & identifies a promising new treatment strategy. Read: bit.ly/4luXCP8 UChicagoCancerCenter Lisa Schweizer Hilary Kenny Ernst Lengyel Matthias Mann Lab Max Planck Institute of Biochemistry (MPIB)

An interdisciplinary study Matthias Mann Lab & UChicago Obstetrics and Gynecology Department uncovers how benign borderline ovarian tumors develop into invasive low-grade serous carcinoma, opening a new avenue for targeted therapy. ❕Publication: cell.com/cancer-cell/fu… ❕Press Release: biochem.mpg.de/when-tumors-tu…

Proud to share our latest work now in Cancer Cell. In collaboration with Max Planck Institute of Biochemistry (MPIB), we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer & propose a promising new therapeutic strategy. sciencedirect.com/science/articl… #LGSC #SBT

Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TLbW6y

Exciting opportunity for a postdoc position with the exceptional Thierry Nordmann on the topic of inflammatory skin disease. A great and inspiring environment that I can highly recommend!

📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression. 🧠🧬🔬 Read: doi.org/10.1016/j.ccel…

New bioRxiv ! With Dr. Maitra Anirban Maitra (MD Anderson Cancer Center) & Nebraska Rapid Autopsy Program, we used AI-powered Deep Visual Proteomics to map early molecular changes in pancreatic cancer precursor lesions. Read: bit.ly/4nAqPK8 #SpatialMedicine #PDAC

Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with OmicVision Andreas Mund Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!

New study from Ralph Weichselbaum and team show high-dose radiation triggers amphiregulin, a protein that weakens immunity and fuels distant cancer spread—pointing to new strategies for blocking its effects. Sean Pitroda, M.D. Andras Piffko University of Chicago Radiation Oncology nature ow.ly/HgVU50Wn6ZY

Excited to see this masterpiece out nature today. In this study, JannaHeide, Andras Piffko, Ernst Lengyel & colleagues Lengyel Lab unraveled molecular mechanisms of NNMT in ovarian cancer and developed a specific inhibitor. A highly promising therapeutic avenue.

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TMSCHQ

Check out the current issue of Cancer Cell featuring our work on the malignant progression of borderline ovarian tumors on its cover. A team effort between Lengyel Lab UChicago Obstetrics and Gynecology Department and Matthias Mann Lab Max Planck Institute of Biochemistry (MPIB).