📢New Preprint alert!🚨 Excited to share my PhD work! SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. biorxiv.org/content/10.110… from Sridhar Sivasubbu Vinod Scaria lab CSIR-IGIB #lncRNA #vascular #zebrafish #coagulation

📣 Check our paper on macrophages, BCG and bladder cancer! 👉doi.org/10.1242/dmm.05… Work spearheaded by the talented PhD student Mayra Martinez-Lopez 🇪🇨! Now in Ecuador launching her career! All the best Mayra Martinez-Lopez 🇪🇨! We unravelled a new step in the BCG MoA using our 🐟#zebrafish xenografts!

Our latest work on the NeuroVascular Unit is out! New insights into neuronal vs. glia differentiation, Notch3 regulation, BBB formation and more! All spearheaded by the one and only Ivan Bassi in close collaboration with @RuizdeAlmodovar! 1/5 nature.com/articles/s4146…

Excited to share new work from my collaborator! A small-molecule screen using Tau-expressing #zebrafish model uncovers a key regulator of microglial synaptic elimination in #tauopathy. Congratulations to the Burton lab! nature.com/articles/s4146…

🧪A team of researchers, led by Helen Farrants & Eric Schreiter, developed a new way for engineered protein biosensors & bright, fluorescent Janelia Fluor dyes to work together, creating a new biosensor for measuring physiological signals in live animals.➡️janelia.org/news/new-biose…

Embryo cells differ a lot from adult cells - but why? In a new paper from the Trista North lab, they show that embryonic blood stem cells use mitophagy, which the adults do not. A great combo of #zebrafish and iPS cells (two systems I love) to show relevance from fish to humans.

Interesting review by Laura Sanchez Piñon: "Knockout, Knockdown, and the Schrödinger Paradox: Genetic Immunity to Phenotypic Recapitulation in Zebrafish" (mdpi.com/2073-4425/15/9…): Phenotypic discrepancies between zebrafish knockouts and knockdowns aren't as wide as once believed!

Great collaboration with Dr. Duong and Dr. Murphy. Also, thanks to Anjelica Rodriguez-Parks for her effort in establishing CUT&Tag in my lab and contributing to this research. …eneticsandchromatin.biomedcentral.com/articles/10.11…

SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and #vascular function. #epigenetics -> embopress.org/doi/full/10.10…

Gα13 controls pharyngeal endoderm convergence by regulating E-cadherin expression and RhoA activation Read this #OpenAccess Research Article by Bo Hu, Fang Lin & colleagues: journals.biologists.com/dev/article/15…

🚨NEW study from our LAB showing the predictive value of Patient-derived Breast Cancer 🐟zebrafish Avatars ! A co-clinical study where we compare the patient clinical response to treatment with their matching 🐟zAvatar! ✨100% ChampalimaudF The Society for Functional Precision Medicine biorxiv.org/content/10.110…

The dynamics & functional impact of tRNA repertoires during early zebrafish embryogenesis Danny Nedialkova et al Max Planck Institute of Biochemistry (MPIB) find increased translational activity during maternal-to-zygotic transition sensitizes maternal mRNA decoding rates to tRNA supply embopress.org/doi/full/10.10…

A zebrafish knockout model of the N-terminal acetyltransferase Naa80 demonstrates that this enzyme is required for actin N-terminal acetylation and normal inner ear development. @medofak_uib OMRF @NAT_machinery Gaurav Rasmus Ree hubs.la/Q02STX1j0

David Ish-Horowicz FRS (1948-2024): outstanding scientific discovery, with a unique touch of selfless humanity An Obituary by Ilan Davis (ilandavis), with his personal reflections on David's unique approach to science and scientific friendship: journals.biologists.com/dev/article/15…

Zebrafish study reveals clues to how inflammation drives scoliosis. elifesciences.org/articles/96831…

1/4 Our bioRxiv, 'Origin of Ewing Sarcoma by Embryonic Reprogramming of Neural Crest to Mesoderm' is now available on bioRxiv! In this study, we explore the enigmatic origin of Ewing sarcoma using our zebrafish genetic cancer models. We revealed that neural crest cells

Excited to share Konstantinos Ampatzis and Kizil Lab's's new paper on #zebrafish 's intracardiac nervous system (IcNS), highlighting the presence of pacemaker-like neurons that partake in heart rhythm—linking cardiac and neuroscience research. nature.com/articles/s4146…

The main study from my postdoc Miguel Godinho Ferreira is out! #Telomerase isn't required for tumor initiation but its lack drives #Cancer #regression later. Regression occurs via tumor-autonomous mechanisms (cell cycle arrest, apoptosis, melanocyte differentiation) and immune rejection.

Excited to share our latest study! Cyclic ruthenium-peptide prodrugs penetrate the blood-brain barrier and target #glioblastoma, activated by light in orthotopic #zebrafish tumor model. A promising step toward innovative therapies! #CancerResearch pubs.acs.org/doi/10.1021/ac…

The outer ear is a mammalian innovation but where did it come from? In our study in nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. nature.com/articles/s4158… 1/n