Modeling Parkinson’s disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines Nature Neuroscience nature.com/articles/s4159…

Could harnessing the brain’s intrinsic cognitive #Resilience mechanisms lead to treatments before onset of #AlzheimersDisease / #Dementia? Learn More on Oct 25 as you JOIN #MSNseminars & hosts Chiang, F-K 江峰逵 & Nicole when they welcome Weill Cornell Medicine’s Sadaf Amin.

Our goal for the #TauConsortium is to foster collaboration between scientists to help research primary tauopathies. An example of this collaboration in action is the Consortium members’ contribution to a PET radiotracer trial in healthy adult patients: nature.com/articles/s4146…

Molecular mechanisms of mitochondrial dynamics we aim to present a valuable framework reflecting current perspectives on how mitochondrial membrane remodelling is regulated. nature.com/articles/s4158…

Where to start? Activity-dependent alternative translation initiation generates multifunctional proteoforms in the brain dlvr.it/TFZJqZ

Mitochondrial fatty acid oxidation drives senescence; science.org/doi/10.1126/sc…

Thrilled to share new work from our lab led by ⁦Mitchell (Min Woo) Kim⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s4158…

New finding on APOE today in Cell: APOE2 and the Christchurch mutation are defective in LDLR binding. Decreased lipidated ApoE-receptor interactions may protect against the pathogenicity of ApoE and its lipid cargoes in lysosomes cell.com/cell/fulltext/…

Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination | Science Magazine science.org/doi/10.1126/sc…

Elated to share my PhD work, new in Science Magazine science.org/doi/10.1126/sc…👩🏻‍🔬 I was struck by how little we knew about the role of biological sex in the brain, especially in response to sex-biased diseases. In #Alzheimers (AD), 60% of patients are women 🧵

Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the brain during both Alzheimer’s disease and ordinary aging, according to preclinical study led by Dr. Li Gan (Gan Lab). Full story: bit.ly/49bdjFS

Congratulations, Dr. Huang!! Gloria defended her thesis today with flying colors. We're so proud of the fantastic science you've done in the past 5.5 years and the energy you brought t lab ❤️🎉

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease: Neuron cell.com/neuron/fulltex…

Big congratulations to Dr. Celeste! On Tues., Dr. Parra Bravo defended her thesis with command and grace. Next, she’s headed to a postdoc in the Rosato lab at Dartmouth. We’re so proud of all she’s accomplished and can’t wait to see her continued contributions to science!