Very fast CRISPR on demand science.sciencemag.org/content/368/64…

eurobioimaging.eu/news/opportuni…

Interested in protein dynamics and #DNArepair? Why not work with the experts at Sofia BioImaging Node? The Node has 2 new instruments for Fluorescence-lifetime imaging microscopy (#FLIM) - and #funding for Bulgarian researchers. Learn more ⤵️ eurobioimaging.eu/news/opportuni…

How does #PlasmaMembrane repair work? This is what Palina Nepachalovich of Maria Fedorova aims to understand using super fast #spinningdisc confocal microscopy 🔬in collaboration with experts at Laboratory of Genomic Stability, our Sofia Node🇧🇬. Learn about this exciting project!⤵️ eurobioimaging.eu/news/observing…

🧬Team led by Alberti_Lab cracks a fundamental #DNADamage question. Broken DNA is held together by an underwater protein superglue💧! Now published in Cell, with new insights for #cancer therapies. Read more ➡️ bit.ly/3SxnU6n #CMCBnews

We are delighted to share that this tour de force is now out, shedding further light on the mechanisms that keep broken ends close. #parp1 #genomestability #dnadamageresponse #parpinhibitor

Congratulations to Bruce Stillman of Cold Spring Harbor Laboratory on winning the ASBMB's Stadtman Award. Join us in Hemisfair Ballroom C2-3 for his award lecture, happening now! #DiscoverBMB

We are happy to share our latest paper “A unified mechanism for PARP inhibitor-induced PARP1 chromatin retention at DNA damage sites in living cells”, out today in Cell Reports. #PARP1 #PARPinhibitor #GenomicStability Hopefully not a boring thread ↓ cell.com/cell-reports/f…

Happy to share that our collaborative work on SARS-CoV-2 VLP dynamics is now available as a pre-print. #SARSCoV2 #COVID19 #virology #tracking #imaging Kinetic landscape of single virus-like particles highlights the efficacy of SARS-Cov-2 internalization. biorxiv.org/content/10.110…

If you are curious whether loop extrusion is required for γH2AX spread and MDC1 recruitment, you can have a look at the most recently published work from our lab out now in iScience #dnarepair #ATM #MDC1 #γH2AX #DDR #loopextrusion #cohesin cell.com/iscience/fullt…

Contributing to efforts toward elucidating the response to replication stress, we provide a precise timescale of fork stalling and restart in live cells, at 30-s resolution (airyscan teaser below). biorxiv.org/content/10.110… #replicationstress #DNArepair #ATR #replication #DNA #RPA

How many PCNA/RPA molecules are loaded and removed per min during fork stalling and restart? How do DDR inhibitors influence these dynamics? We estimate these rates in our pre-print, out on bioRxiv: doi.org/10.1101/2024.1… #microscopy #DNArepair #genomestability #DNA #replication

”David Baker, Demis Hassabis and John Jumper, your ground-breaking work in computational protein design and protein structure prediction has revolutionised these fields. It has opened up completely new possibilities to design proteins that have never been seen before, and we now

Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 EMBL Annual Poster to include even more courses and conferences for you to join, so go and have a look! ➡️ s.embl.org/poster-x #EMBLEvents #molecularbiology #lifesciencetraining

nature.com/articles/s4146… We are glad to see further evidence confirming our finding that loop extrusion is dispensible for the spread of gH2AX (doi: 10.1016/j.isci.2024.110826). #loopextrusion #cohesin #dnarepair #DDR #DSB