🚨In this prespecified analysis of the AcT RCT, we examined safety & efficacy outcomes of thrombolysis with tenecteplase & alteplase in elderly patients. 23% mRS 0-1 among >=80y vs 43% <80y. No difference in sICH. ahajournals.org/doi/10.1161/ST… nishita singh DCNS Calgary Bijoy K Menon

🚨Check out the new blog post from rising undergrad researcher (and Avenue Calgary Magazine Top 20 Under 20) Nikhil Srivalsan on "The Future of Nanomedicine: Tiny Solutions to Big Health Problems" letsgetproof.com/blog/the-futur…

🙏 for the opportunity to analyze the #TEMPO2 data with a sex disaggregated lens 👉♀️ were less likely to achieve baseline mRS than♂️ after TIA/minor stroke 👉⬆️ recanalization with TNK, but no clinical benefit ShelaghCouttsMD Michael D Hill JAHA ahajournals.org/doi/epub/10.11…

🚨Can 24h NIHSS be a primary outcome for acute stroke RCTs? 24h NIHSS results aligned with 90d mRS in 84% of RCTs, but early NIHSS risks misclassifying 1/4 patients doi.org/10.1161/JAHA.1… Johanna Ospel, MD PhD Manon Kappelhof Rosalie McDonough Michael D Hill Mayank Goyal Stroke AHA/ASA DCNS Calgary

🚨In focus groups for ACT-GLOBAL, our ongoing stroke adaptive platform trial, patients & caregivers supported APT design but identified priorities re: execution to safeguard patient autonomy & safety doi.org/10.1159/000546… Bijoy K Menon Karger Publishers DCNS Calgary The George Institute for Global Health

🚨 New blog post by student researcher Praveer Bal on Hypertension, the leading preventable cause of stroke and heart disease 🧠🫀 Learn about the different forms of hypertension and how to treat it! letsgetproof.com/blog/hypertens…

🚨 New blog post by student researcher Praveer Bal on Hypertension, the leading preventable cause of stroke and heart disease 📷letsgetproof.com/blog/hypertens…

🚨 Cherry picking of patients can be a major problem in acute stroke trials. Mayank Goyal and I discuss factors contributing to cherry picking (such as the What's In It For Us [WIIFU] problem) + how we might measure and mitigate it: ahajournals.org/doi/10.1161/ST… DCNS Calgary Stroke AHA/ASA

🚨 🧠Why do patients with occlusions in the same location present with very different neuro deficits? We find that brain frailty may be part of the answer, being associated with baseline stroke severity +NIHSS recovery trajectories neurology.org/doi/10.1212/WN… Neurology Journal DCNS Calgary

🚨Time for the stroke world to drop recertification & retraining requirements for NIHSS & mRS! Our systematic review found NO evidence of benefit from this endess exercise doi.org/10.1017/cjn.20… Led by Davis Maclean UCalgaryMedicine w/ Diana Kim ShelaghCouttsMD Rick Swartz Canadian Journal of Neurological Sciences

🚨Frailty and Stroke 🧠- this World Stroke Org Scientific Statement emphasizes the importance of conducting stroke trials in frail populations to inform evidence-based care: journals.sagepub.com/doi/10.1177/17… Thanks Nicholas Evans for leading this work! Dr Terry Quinn💙 Dorcas Gandhi and many others

🚨What if you could get a measure of someone's atherosclerotic burden right from a plain CT scan? Our pilot study on Arterial Brain Calcium (ABC) volume- a marker of athero & future stroke risk on non-contrast CT- now out in JSCVD: sciencedirect.com/science/articl… Diana Kim DCNS Calgary

🚨 Multiple Sclerosis is a neuro disease for which med research has made major strides over the past decades. Check out our latest blog post from Arshdeep Bhullar on Clinical Manifestations, Diagnosis & Clinical Course of MS! (therapeutics post to follow) letsgetproof.com/blog/multiple-…

🚨🧠Reflections and comments on our study of brain frailty and stroke severity in American Academy of Neurology Neurology Journal Joachim Fladt, MD DCNS Calgary neurology.org/doi/10.1212/WN… Thank you Neurology Today!

🚨In our latest blog post, Jaanya Lal discusses what happens in our brains when our immune system turns against us, “From Defence to Danger”: letsgetproof.com/blog/defence-t…

The Canadian Outcome Scale for Minor Stroke (COSMOS): a much-needed, novel 7-point scale to assess more Individualized outcomes in patients with minor stroke (mRS is not sufficient). Stroke AHA/ASA Kudos to Mayank Goyal Aravind Ganesh Salome and team. ahajournals.org/doi/10.1161/ST…

🚨 We created the Canadian Outcome Scale for Minor Stroke (COSMOS) to better capture the spectrum of good to poor outcomes in minor stroke. Here, we present COSMOS and its high inter-/intra-rater reliability:🇨🇦🇨🇦🇨🇦ahajournals.org/doi/abs/10.116… Mayank Goyal nishita singh Stroke AHA/ASA

We have also created a free training and certification program for COSMOS to facilitate its adoption in future clinical trials and cohorts worldwide: letsgetproof.com/lgp/the-canadi… Let's Get Proof 👨‍🏫👩‍🏫🌎🌍🌏

🚨 In this worldwide Practice Current survey of neurologists on mgmt of MCI, there was cautious optimism re: anti-amyloid therapies, with concerns about side effects but a general interest to prescribe: neurology.org/doi/10.1212/CP… Graham McLeod, Aaron Switzer, Eric Smith DCNS Calgary