Hanging out on the balcony with lab peeps. Rohan Sharma and Leonardo Parra-Rivas gave great talks. Big Brent (red T) still to come at 1:45 today. #SfN2022

It's a wrap #SfN2022 we ended with a bang!

The past seven days have been very intense but quite enjoyable. I met great new people at the Brightfocus workshop, saw old friends and mentors #SfN2022 , and had my first research talk there. PPR submission next :)

I just learn that one of my synaptic heroes and author of one of my favorite books passed. RIP Chuck! Famed Neuroscientist Charles Stevens Dies at 88 the-scientist.com/news-opinion/f…

Phosphorylation of alpha-synuclein at Ser-129 is a pathologic hallmark of Parkinson's+. Normally, only ~ 4% is Ser129P, so almost all studies have focused on pathology. Surprisingly, we found that Ser129P has a role in normal a-syn function: biorxiv.org/content/10.110… 🧵👇1/8

👏 So please congratulate Launch Awardee leonardo parra 🇨🇱, who will study the physiological roles of Serine-129 phosphorylation of a-synuclein UC San Diego Health Sciences. Felicitaciones!!! (2/2) Parkinson's Foundation

And here is @leonaedoparrar highlight! 👇

Alpha-synuclein needs Synapsin-E domain (48 amino-acids) to do its day job - co-first authors Alexandra (Sasha) Stavsky & Leonardo Parra-Rivas

Day 23 of great biology papers. "The genetics of Caenorhabditis elegans," by Sydney Brenner (1974). 7 years, 300 worm mutants, 100 genes. This paper kicked off Brenner's long-term aim: To map how every gene affects the "development and functioning" of a multicellular organism.

With my scientific grandmother Virginia Lee :)

🏅 Many awardees also came to celebrate with us and have the best of times: 2022 Impact @benjamindehay, 2021 Fahn De Biase Lab, 2018 Postdoc/2023 Fahn @bdemiranda, 2023 Launch Leonardo Parra-Rivas (3/4) Parkinson's Foundation

Great to Leonardo Parra-Rivas in this group...

🇨🇱 Mi amigo y 2023 Launch Awardee Leonardo Parra-Rivas is a very busy man, as *everyone* wants to hear about his work "Serine-129 phosphorylation of a-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function". Parkinson's Foundation

2023's final issue is out! cell.com/neuron/current Cover story is from Subhojit Roy's lab revealing an unexpected physiologic role for α-synuclein phosphorylation in clustering synaptic vesicles and restricting neurotransmitter release. Read it here cell.com/neuron/fulltex…

Massive 10+ year effort in lab spearheaded by Leonardo Parra-Rivas and Kayal (secret account 🤔). Unreal cover by Emma VIDAL that says it all.

Interesting: Leonardo Parra-Rivas Subhojit Roy, MD, PhD & colleagues present a role for α-synuclein Ser129P at synapses, where activity-induced Ser129P triggers the interaction of α-syn with synaptic proteins leading to attenuation of neurotransmitter release cell.com/neuron/fulltex…

#ADPD2024 Michael J.Fox and Ron Lauder

Excited to present my Parkinson’s Foundation(Parkinson's Foundation)-supported research on α-synuclein S129 at synapses at #ADPD2024 Portugal. Join my talk on Saturday, March 9th, 3:40 PM, Session: 6880 - α--SYNUCLEINOPATHIES: MECHANISMS, PATHOPHYSIOLOGY AND MODELLING OF PROGRESSION

Unlocking the mysteries of neuronal communication! 💡Our new research sheds light on reserve synaptic vesicle dynamics, spotlighting Synapsin 2a’s crucial role. #NeuroScience #SynapticVesicles #BrainResearch Fred Meunier 🌟🔬Read more: rdcu.be/dA1ux

Gene editing of APP C-terminus rescues neuropathology, ephys, behavior, and transcriptomic changes in #alzheimer knockin mice. Led by Brent Aulston, collaboration with labs of Krishanu Saha Mark Zylka Marcelo Wood Jon Audhya (Madison) #crispr #therapeutics biorxiv.org/content/10.110…