Very happy to share the results of my Marie Skłodowska-Curie Actions project done at UCL Genetics Institute with Mark Thomas and Pontus Skoglund from The Francis Crick Institute. We used ancient DNA to reveal remarkably high genetic diversity in the region of modern-day Ukraine / Україна over the last 3,500 years until ~500 years ago.

(1/6) Excited to share our manuscript describing Quickdraws, a novel algorithm and software to perform GWAS that increases association power while keeping computational costs low. More details below (thread). Link to article: nature.com/articles/s4158…

A genealogy-based approach for revealing ancestry-specific structures in admixed populations biorxiv.org/cgi/content/sh… #biorxiv_genetic

Delighted to see our new paper out in Nature nature.com/articles/s4158…

Our new paper is out! Congrats to the whole team, especially the staff and students Bournemouth Uni who have been excavating this incredible site for 15 years (with much more left to uncover!) Widespread matrilocality in Iron Age Britain - Up Na Mná :) rdcu.be/d6mb0

One week to the abstract submission deadline for SMBE 2025, Beijing 20-24 July! smbe2025.scimeeting.cn Anastasia Ignatieva and I are organising a symposium on popgen through time: using ARGs, aDNA, or otherwise to understand the evolutionary processes that shape genomes through time.

Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵

Excited to share our preprint "A putative ecocline in Klebsiella pneumoniae" and super-interested to get your feedback. Really want to use the hive mind to get to the bottom of this phenomenon ASAP. biorxiv.org/content/10.110…

Excited to see my project at University of Oxford finally published at Nature Genetics ! Huge thanks to my co-authors Simon Myers Daniel Lawson Jonathan Marchini Garrett Hellenthal Lino Ferreira Sinan Shi , and the reviewers/editors. Read the publication here: nature.com/articles/s4158… 🚀🎉

Congratulations Sile! And really fascinating & clean result seeing conservation of effect sizes across human groups using local ancestry in admixed people!

Our papers, out today in @nature, show how ancient DNA from the Eneolithic and Bronze Age steppe points to a North Pontic origin of the Indo-European language family and a Caucasus-Lower Volga (CLV) origin of Indo-Anatolian (inclusive of the now extinct Anatolian languages). 1/

Applications are now open for the #EMBOpopgen course - deadline 24th Feb! All information here: meetings.embo.org/event/25-pop-g…

これまで統合生物考古学セミナーや進化学会夏の学校などで扱ってきました内容を中心に，「ゲノム多様性解析」として森北出版から出版予定です．多くの方のご協力を仰ぎました． 類似の日本語教科書はないと思いますので，ご興味のある方はぜひ手にお取りください． morikita.co.jp/books/mid/0261…

I have a 2 year postdoc position available on our 'COREX: from correlations to explanations' grant: cordis.europa.eu/project/id/951…. See: ucl.ac.uk/work-at-ucl/se…... working at the intersection of archaeology, computational modelling and stats. Starts Nov 2025.

Our new paper is out in Science Magazine! By exploring the rich genetic diversity of Brazil, we show how fine-scale genomic analyses reveal that this diversity, rooted in Indigenous ancestry and centuries of complex demographic history, plays a key role in population health.

New from Tianyi Wang in Science science.org/doi/10.1126/sc…

Postdoc position in my group in Tokyo! Please get in touch if you are interested. And happy to discuss projects - ranging from developing new methods to analysis of new genomes that we are now sequencing in the lab. riken.jp/en/careers/res… Lab page: speidellab.github.io

インタビュー【MEET a rising star at RIKEN】 理研で活躍する若手研究者が理研の魅力や研究環境、日々の暮らしを語ります。第1回はシュパイデル玲雄（Leo Speidel）理研ECLユニットリーダー。数学・統計学を用いてヒトの進化・歴史を追求しています。 📹 youtu.be/T-4VhIbllow

🚨New preprint out! 🧬Short reads can now decode centromeres. 🌍We reveal population-scale centromere haplogroups and their links to disease. biorxiv.org/content/10.110… (1/n)

Tracing our ancestors’ #genomic footprints: Leo Speidel. Leo Speidel #ancestry #riken riken.jp/en/about/peopl…