Think the cytoplasm is well-mixed? Think again. In my latest work with Dr. Arthur Molines 🎮 and Fred Chang we found the apparent viscosity of the cytoplasm may vary up to 100-fold (!) within individual cells, and 10-fold (!) between cells. A thread: (1/8) biorxiv.org/cgi/content/sh…

Thrilled to be awarded the 2023 Breakthrough Prize in Life Sciences together w/ Tony. An amazing journey we've been on, and the work of countless students, mentors, & colleagues, as well as the support of family & friends, have made this all possible.

Looking for the latest on integrin-mediated adhesions between cell and ECM? ⛓️ Check out this new review (with beautiful figures) by Tony Kanchanawong and David Calderwood lab in Nature Reviews Molecular Cell Biology here ⬇️ 🔗 nature.com/articles/s4158…

In synthetic biology classes, I ask students what biological function they want to create, and one popular answer is "photosynthesis in mammals". Now, it's achieved! The authors transplanted membrane-coated thylakoids into chondrocytes and mice! Congrats! nature.com/articles/s4158…

As an academic writing coach, here are the 9 mistakes I see PhD and grad students make when writing scientific papers. A thread. 🧵 #PhDchat #ECRchat

The FixEL paper (Chem, 2023) for small molecule 3D imaging in tissues was highlighted in Chem as follows! Make it stick: Fixable ligands for tissue imaging cell.com/chem/fulltext/…

I’ve posted this one before, but today seems like a good fit for this image of a kidney glomerulus and nearby axon doing its best to look like a rose.

Label-free 3D traction force microscopy. New application of holotomography. biorxiv.org/content/10.110… #biophysics #microscopy #cell #dynamics #mechanics

#IntrinsicallyDisorderedProteins in the center of the pore of the nuclear envelope can form spaghetti-like barrier permeable for cellular factors but blocking viruses and pathogens press.uni-mainz.de/how-wiggly-spa… #biophysics Lemke Lab IMB Mainz SFB 1551 - Sonderforschungsbereich 1551 SPP2191 - Mol. Mech. of Funct. Phase Separation Max Planck Institute of Biophysics Hummer Lab nature

Anyone have an example of where a protein has two very different (or even opposite) functions depending on the biological context (e.g., cell, developmental stage, sex, etc.)?

#ICBP2023

The longer people are in academia, the more they realize that when reading papers it's best to ignore Intro, Discussion etc. and just look at Methods and Results journals.plos.org/plosone/articl…

"AlphaFold2 can predict single-mutation effects" has been updated Rather than use pLDDT, which does not work, these authors use a local strain score to predict the effect of mutations biorxiv.org/content/10.110… github.com/mirabdi/PDAnal…

Not enough people know about bioicons.com Open source vector graphics. Free alternatives to BioRender.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

This year’s chemistry laureates Demis Hassabis and John Jumper have developed an AI model, AlphaFold2, to solve a 50-year-old problem: predicting proteins’ complex structures. Check out two examples of protein structures determined using AlphaFold2. First up, a bacterial enzyme

BREAKING NEWS The 2024 #NobelPrize in Literature is awarded to the South Korean author Han Kang “for her intense poetic prose that confronts historical traumas and exposes the fragility of human life.”

Molecular dynamics simulations in mixed reality! With Luciano Abriata and Lucien Krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! Three.js #WebXR #Quest3