Out Now! An updated evolutionary classification of CRISPR–Cas systems including rare variants bit.ly/4oUjsNx #CRISPR #Genetics #Biotechnology

Tonight’s episode of 60 Minutes will include a segment on the impact of federally funded science and recent cuts to science funding. Our lab’s development of base editing and prime editing and their clinical applications will be among the work described in the episode.

Mitochondria were never engines, they’re brakes coming off. Biology sold you a factory, a furnace, a tiny power plant, because it made the math easier, but the reality is older and simpler: life isn’t powered by something being “made,” it’s powered by something being released.

These are Cat embryos right before we used CRISPR gene editing to knockout the primary allergen gene Fel D1 on our quest to create a true hypoallergenic cat at Embryo Corp (implants soon)

We usually learn vitamins as a list, but biology doesn’t use lists. It uses systems. If you look at this chart the right way, it isn’t a collection of nutrients. It is a map of the reactions that keep you alive. 1️⃣ Vitamins are the switches that turn metabolic pathways on They

Este 2025 he leído algunos libros muy buenos y otros buenos. He abandonado algunos libros muy malos y otros malos. Pero, sin lugar a dudas, este es el mejor libro que he leído este año. Todo el mundo debería leer a Elizabeth Taylor, todo el mundo debería leer este libro.

En los últimos días han aparecido una serie de valientes columnas de opinión acerca de la situación en la Universidad Nacional de Colombia. Aquí va un 🧵 con mis favoritas. La magistral pluma del profesor Moisés Wasserman escribe “La declaración de desobediencia civil de Gandhi para liberar el

#FotogaleríaUNAL Al final del semestre la Hemeroteca Nacional se convierte en un segundo hogar para estudiantes que buscan concentrarse y cumplir con sus metas académicas en la jornada “Biblioteca 24 horas” 👉 ow.ly/PPuj50Xzcvp Vía Prensa UNAL - Universidad Nacional de Colombia | #SomosEducación

A beautiful demonstration of individual genes producing multiple proteoforms with different subcellular localizations. Alternative translation initiation sites generate N-terminally truncated proteoforms that localize to different cellular compartments.

I spent 1.5 years at MIT co-designing a new undergrad program in Genetic Engineering. The full report is now publicly available. It describes what needs to be built to educate the next generation, and why. Appendix II includes notes from interviews with 100+ biotech company

2025: research in review go.nature.com/4oCK84L

Estoy En Medellín, Colombia, hay una esquina en el barrio Manrique donde todos los días aparecen sándwiches. A las 3am. Exacto. Envueltos en papel aluminio. En una bolsa plástica. Colgando de un poste. Nadie sabía quién los dejaba. Los habitantes de calle del sector los

Demonizamos la "zona de confort" como si la paz fuera un fracaso. Para quien viene del trauma o el caos, la rutina aburrida es un éxito terapéutico, no estancamiento. Quedarse quieto y sentirse seguro también es salud mental. No todo en la vida tiene que ser un reto constante.

Every paper needs a clear positioning strategy. Only three options exist: 1. Fill a gap (nobody studied this) 2. Extend research (we go further) 3. Correct errors (prior work was wrong) Pick one. State it in your intro. Reviewers need to know why you exist.

Your team reads 50 papers but remembers nothing. Give them a paper annotation method. 4 questions for every paper: • What's the aim? • Key findings? • Methods used? • Gap it reveals? Standardize reading. Build institutional memory. Active reading beats volume.

This paper is wild. After 3 rounds of directed evolution, they converted a DNA polymerase into an enzyme that can do: - RNA synthesis - Reverse transcription - Synthesis of "unnatural" nucleotides - Synthesis of DNA-RNA chimeras One of the best papers I’ve read recently. For

Having been in the genome engineering field for a few years 🦣🐺🦤 I have to say this paper from Jennifer Doudna's lab is very interesting. Amplified genome editing by in vivo editor production biorxiv.org/content/10.648…

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Escribí sobre la enfermedad de Huntington en el Caribe: una mutación genética transmitida de padres a hijos. Sobre mujeres obligadas a tener hijos que luego se enfermarán. Y niños que pasan su infancia a la espera. Sobre el amor, el dolor y el cuidado. mutante.org/contenidos/los…

modern research equipment is absurdly expensive. • a lab power supply • a microscope • a 3d printer • a spectrometer each can cost thousands of dollars. but most of these machines are just combinations of: • motors • sensors • microcontrollers • mechanical frames •