✨ New from C-GEM: High yield, low magnesium flexizyme reactions in a water-ice eutectic phase 💧🧊 Congrats to Josh, Jose, Mace, Evan, Angelin, Isaac, Schepartz Lab, @aaronengelhart and Kate Adamala! #NSFfunded #synbio biorxiv.org/content/10.110…

✨ New from C-GEM: A translation-independent directed evolution strategy to engineer aminoacyl-tRNA synthetases Congrats to Chintan Soni Savage Lab Alanna Schepartz Abhishek Chatterjee on a wonderful collaboration! #NSFfunded biorxiv.org/content/10.110…

Congrats to C-GEM grad students Isaac, Noah, and Leah!! 🎉

The Women Chemists Committee (WCC) of the American Chemical Society is pleased to announce the winners of the 2024 WCC Merck Research Award. We thank all those who applied for this competitive scholarship and to Merck for sponsoring this award.

Congrats to C-GEM grad student Leah Roe, a 2024 WCC Merck fellow! #NSFfunded College of Chemistry

It’s been a while, but there’s no time like the present to remind everyone that the Minute for Diversity slide is a great and easy way to add community in your lab/department. Please share with your friends and colleagues!

Years later we are still doing it! Thanks Leah! :)

Incorporation of Multiple β2-Hydroxy Acids into a Protein In Vivo Using an Orthogonal Aminoacyl-tRNA Synthetase NEW #ASAP by Alanna Schepartz & colleagues UC Berkeley MCB Read it here: go.acs.org/9CQ

Mutations in the kinase domain of RTKs like MET can drive disease. Small molecule inhibitors target these mutations, but acquired resistance poses a challenge. In our latest preprint, we've extended our previous 🧬DMS of MET to study this exact problem. doi.org/10.1101/2024.0…

Come learn about BEAR next weekend at ACS Denver! And a huge thanks to WCC/Merck for hosting me 🙂

My favorite and hardest NMR experiment ever conducted is finally out! Congrats to everyone involved, but especially Daphne for pushing the project to the end 🎉🎊

Are you applying for the NSF #GRFP? Check out our "demystifying the GRFP" blog series! gem-net.net/introduction-t… Leah Roe writes about: 🗒️the application 🧪 research proposal ✍️ personal statement and @sarahsmaga shares advice on asking for letters of rec 📨

🚨 We discovered a new genetic code, "Genetic Code 34," sporadically distributed in archaea. Select archaea have genome-wide recoding of the TAG stop codon to pyrrolysine; the adoption of this code was likely driven by metabolic processes. (1/2) biorxiv.org/content/10.110…

New preprint: a new genetic code in select archaea! I'd like to thank my co-authors for their amazing work - it was so much fun working together on this project!

✨ New preprint with collaborators in The Banfield Lab! biorxiv.org/content/10.110… Congrats to Veronika Kivenson Leah Roe @NoahXHamlish et al on a really fascinating story (tweetorial below ⤵️) #NSFfunded

I created a protein backbone editing method and named it after my alma mater (x2)! Out now in Nature ChemBio, we show the first examples of a β2-, γ-, and δ-amino acid encoded into full length proteins expressed in cells. nature.com/articles/s4158…

A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-, γ-, or δ-peptide backbone nature.com/articles/s4158…

Our work NSF Center for Genetically Encoded Materials on co-translational incorporation of a noncanonical monomer into a protein, followed by its triggered post-translational chemical rearrangement, yielding novel backbone modifications. nature.com/articles/s4158…