Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies biorxiv.org/content/10.110…

What’s the relationship between #AmyloidBeta and tau protein? New research involving #AlzheimersDisease patient PET and fMRI data reveals amyloid-beta may drive tau spread through hyperconnectivity between vulnerable brain regions. Nico Franzmeier Sebastian Roemer-Cassiano scim.ag/3CfY6aR

FUS post-transcriptional splicing is autoregulated via RNA condensation with therapeutic potential for ALS-FUS: biorxiv.org/content/10.110…

Expanding the molecular grammar of polar residues and arginine in FUS phase separation: nature.com/articles/s4158…

Aging-dependent evolving electrochemical potentials of biomolecular condensates regulate their physicochemical activities. doi.org/10.1038/s41557…

Aggregation of α-synuclein splice isoforms through a phase separation pathway | Science Advances science.org/doi/10.1126/sc…

Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons science.org/doi/10.1126/sc…

Solid phase transitions as a solution to the genome folding paradox nature.com/articles/s4158…

New online! Distinct tau filament folds in human MAPT mutants P301L and P301T bit.ly/3Sqik65

Lipidomic profiling of mouse brain and human neuron cultures reveals a role for Mboat7 in mTOR-dependent neuronal migration science.org/doi/10.1126/sc…

Triglycerides are an important fuel reserve for synapse function in the brain go.nature.com/4nvjk7k

Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of Sofi Quinodoz & Lifei jiang w/ Denis LJ Lafontaine & Sebastian Klinge and other fantastic co-authors nature.com/articles/s4158…

Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson’s disease rdcu.be/evdQy

Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders science.org/doi/10.1126/sc…

🧬 𝗙𝗲𝗮𝘁𝘂𝗿𝗲𝘀 𝗼𝗳 𝗙𝗿𝗮𝗴𝗶𝗹𝗲 𝗫–𝗔𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗲𝗱 𝗧𝗿𝗲𝗺𝗼𝗿–𝗔𝘁𝗮𝘅𝗶𝗮 𝗦𝘆𝗻𝗱𝗿𝗼𝗺𝗲 𝗼𝗻 𝗠𝗥𝗜 Shown are a T2-weighted MRI scan of the middle cerebellar peduncle with signal change (Panel A, arrow; axial view), signal change in the splenium of the corpus

Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease pnas.org/doi/10.1073/pn…

Lipidic folding pathway of α-Synuclein via a toxic oligomer rdcu.be/exZq5

Structure of ATTRv-F64S fibrils isolated from skin tissue of a living patient biorxiv.org/content/10.110…

Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 rdcu.be/eAn5C

Risdiplam in Presymptomatic Spinal Muscular Atrophy nejm.org/doi/full/10.10…