Chromatin profiling reveals genome stability heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus biorxiv.org/cgi/content/sh… #bioRxiv

Just out in @PNASnews secondary metabolite gene clusters of >1,000 fungi 🍄🧬 reveal distinct chemical reservoirs important for drug-discovery and the evolution of #fungi. #Genomics In collaboration with @NLKproteomics: pnas.org/content/118/19… Ft. @hailceezur Milton T Drott

from 5 GB to 74MB is the difference between the gzip and xz (lzma) formats for storing the 1.4m SARS-CoV2 genomes. This file would have taken 39GB uncompressed.

Samplot: from Jon Belyeu, Chowdhury, ryanlayer and co, for visualizing read alignment at suspected structural variants, to aid manual curation of SVs. Human input is a good way of resolving false positives from automated SV callers. genomebiology.biomedcentral.com/articles/10.11…

“We were quite gobsmacked by how much repetitive DNA was in there due to these transposable elements” bit.ly/34JXiGJ

Taking time to savour this moment: my first senior author paper published today in Genome Biology. I'm incredibly proud of this work & I couldn't have done it without Jovana Maksimovic. Thanks Alicia Oshlack for allowing me the space & time to lead this work. genomebiology.biomedcentral.com/articles/10.11…

Excited to share our paper showing how Aspergillus spores proactively prepare for their future (through staying transcriptionally active and responsive) before entering dormancy. By a talented PhD student (Fang Wang) with helps from other lab members. nature.com/articles/s4156…

Proud to share our latest work on #Candida glabrata identifying a transcription factor important for #macrophage_response and #drug_resistance. By a team of talented post docs and students. biorxiv.org/content/10.110…

In our new paper we describe patterns of mutation accumulation in a fungal pathogen. One year of cell divisions and evolution in 280 isolates including mutants impaired in heterochromatin formation, and isolates with/without DNA methylation. See: nature.com/articles/s4146…

Excited to share our study defining the #pangenome of Aspergillus fumigatus and what it told us about virulence and drug-resistance! Out now in Nature Microbiology.

How cool is this! Soil fungus uses a bacterial metabolite (produced endocymbiotically) to protect against nematodes! Bacterial endosymbionts protect beneficial soil fungus from nematode attack pnas.org/content/118/37…

Keynote talk by Sophien Kamoun at #EPSLunteren2022 #EPS2022

Our story on how orthologous gene #coevolution 🧬 can be used to provide insight into cellular and genomic structure and function is now published in Science Advances 😊😊 A 🧵 summary 🔗: tinyurl.com/56f4ktkx #evolution #biotech #science #research #molecularbiology #biology

👋 I've made a new #dataviz related website! 😀 It's called☀️dataviz-inspiration.com: a list of many stunning Viz projects I love💜 🧵

Excited to share a paper on a novel chromatin complex that connects Fungal Development and Secondary Metabolism. Made possible with collaborative efforts from many labs TheKellerLab, FungalGenetics-StraussLab, #StefanGraessl, Dr. Mohamed Alhussain, led by @obayram54. academic.oup.com/nar/advance-ar…

Highly informative talks on ANI, species diversity and obviously the pangenomics…

Ten interesting things we learned about phages while editing this article for Asimov Press: 1. You can buy phage therapies over-the-counter at some pharmacies in Georgia. (The country. Not the state.) 2. An oft-cited estimate is that by 2050, at least ten million people could

Excited to share our research where we trace prophages in the Pectobacterium genus pangenome to understand their contribution to genomic heterogeneity.

Published in Microbiology Society tinyurl.com/4248jyuv highlighting: - Contribution of #prophage dynamics in the #pangenome evolution - Pangenome data structure to trace orthologous prophages - Generalist & specialist prophages in the Pectobacterium genus