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The Conformational Equilibria of a Human GPCR Compared between Lipid Vesicles and Aqueous Solutions by Integrative 19F-NMR | Journal of the American Chemical Society Matthew Eddy Arka Ray FLORIDA pubs.acs.org/doi/10.1021/ja…

Aza-Michael Addition–Fragmentation Ring-Opening Polymerization | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

We shared early clinical data at our Research and Development Day showing encouraging results from our next-generation #ADC programs. Our first-in-class FGFR3-directed ADC has also entered the clinic: bit.ly/4joA2C2 #MedEd #MedX

Lysine-Targeted Covalent Strategy Leading to the Discovery of Novel Potent PROTAC-Based PI3Kδ Degraders | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Excited to share that Dr Singh will be speaking at the upcoming Cell Symposia: Gene and Cell-Based Therapies – Progress in Clinical Translation taking place November 2–4, 2025 in Los Angeles, CA #CSStemCells2025 Cell Stem Cell Cell Symposia

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks, and mechanistic screening nature.com/articles/s4158…

After a multi-year journey to bring thianthrenation-like chemistry to water, we now present a selenoxide reagent that can be used to perform single atom modifications selectively on tyrosine residues in proteins or peptides! Out now in Nature Chemistry! nature.com/articles/s4155…

🚨RSC Chemical Biology is online and #openaccess! Cover: John Pezacki et al., "Monitoring SARS-CoV-2 Nsp13 helicase binding activity using expanded genetic code techniques" 👉Read: doi.org/10.1039/D4CB00… 👉Meet our Emerging Investigators 2024: doi.org/10.1039/D5CB90…

Nominations are now open for the Abeles-Jencks Award for the Chemistry of Biological Processes! Submit letters of nomination (1000 words), support (500 words, 1-3), and candidates CV to BIOL Division Secretary [email protected] by Monday, July 7. divbiolchem.org/awards/abeles-…

Biophysical Approaches for Investigating the Dynamics and Cooperativity of Ternary Complexes in Targeted Protein Degradation | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Every Day a Different Chemical Reaction #190 Synthesis of Enynal Donors at Gram Scale

β-Thioglycosylation from Unactivated Carbohydrates | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells | Journal of the American Chemical Society Dan Nomura pubs.acs.org/doi/10.1021/ja…

For readers interested in bispecific antibodies in oncology, here's a comprehensive review nature.com/articles/s4157… rdcu.be/eqxm5

A highly compact chemically induced proximity system dependent on salicylic acid or aspiring enables control of biological processes and cellular therapeutics using an over-the counter drug with minimal side effects nature.com/articles/s4158…

Check out the associated News & Views by Yang Zhou, Xiaoding Ma, and Haifeng Ye on the innovations of this chemically induced proximity system called SAMBA nature.com/articles/s4158…

Folate receptor alpha-targeting chimeras (FRTACs) are developed for targeted membrane protein degradation by conjugating multiple folate molecules to antibodies. The folate polyvalency enables high affinity and potency of FRTACs to target proteins nature.com/articles/s4158…

Recent advances in the development of covalent inhibitors - now published in RSC Medicinal Chemistry pubs.rsc.org/en/content/art…………………………… #chemistry #Bioinformatics #ChemicalProbes #MedicinalChemistry

Controlled/″Living″ Click Polymerization with Possible Bidirectional Chain-Growth Propagation during Polyaddition | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Isomerization of Poly(ethylene glycol): A Strategy for the Evasion of Anti-PEG Antibody Recognition | Journal of the American Chemical Society Universität Mainz pubs.acs.org/doi/10.1021/ja…