New paper: split-intein Gal4 provides intersectional genetic labeling that is repressible by Gal80. Ewen-Campen, Luan, Xu, Singh, Joshi, Thakkar, Berger, White, Perrimon. PNAS. 2023 doi: 10.1073/pnas.2304730120. Epub 2023 Jun 5. PMID: 37276389

Thanks Fillip Port! Nice #CRISPR clones showing that the TNF Receptor wgn plays an important role in lipid metabolism in the #Drosophila intestine. science.org/doi/10.1126/sc…

How do animals weigh competing needs to maintain nutrient and fluid balance? Check out our recent review in #BioEssays in which we aim to provide a framework for understanding the polymodal optimization of homeostasis in insects. Also, pretty pictures... onlinelibrary.wiley.com/share/EU9FPTNI…

Fresh preprint! Collaborative work with Chris Wegener's lab looking at the release of clock neuropeptide pigment dispersing factor.

If you are interested in how genes are regulated in response to dietary sugar, please check out our recent publication 'Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange': cell.com/cell-reports/f… 1/

Curious about how some beetles have evolved to drink, not with their mouths, but with their rectum? Check out our latest Quick Guide in the current issue of Current Biology. In collaboration with Robin Beaven Denholm Lab sciencedirect.com/science/articl…

Our last review: Drosophila TNF/TNFRs: At the crossroad between metabolism, immunity, and tissue homeostasis J. Colombani & D.S. Andersen - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/18…

Our preprint on #Obesity-driven #InsulinResistance reveals a muscle-neuronal-fat axis adapting to high-sugar-induced obesity conditions by influencing insulin secretion & sensitivity in #Drosophila. @Halberglab biorxiv.org/content/10.110…

Michael Ashburner (1942-2023). Rubin GM. Curr Biol. 2023 Aug 18:S0960-9822(23)01072-2. doi: 10.1016/j.cub.2023.08.029.

Let's try this again - look's like twitter can't handle the video 😂. Really excited to share the lab's first Drosophila paper and it's a big one. Check out our preprint shorturl.at/gqrvO where we present the complete neural connectome of an animal circadian clock

New paper: Petsakou, A., Liu, Y., Liu, Y. Comjean, A., Hu, Y. and Perrimon, N. Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut. Nature (2023). doi.org/10.1038/s41586…

Online now! Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila dlvr.it/SyTZ2L

Latest from the lab: What are the mechanism by which insects maintain systemic ion and water balance as they interact with their environment? Another great collaboration with Denholm Lab!annualreviews.org/eprint/FXMYNQH…

We are excited to share our recent work on gut-to-glia communication linking intestinal inflammation with sleep in #Drosophila! Many thanks to HalbergLab and Andersen and J. Colombani & D.S. Andersen lab! Lundbeckfonden Novo Nordisk Foundation Carlsbergfondet University of Copenhagen Research biorxiv.org/content/10.110…

Thrilled to share our work! Thanks to @NovoNordiskFond and DK Frie Forsk.fond, we unveil how LGR signaling mediates crosstalk between muscle, neuronal, and adipose tissues, protecting against #insulinresistance and offering insights into #Diabetes and #Obesity. nature.com/articles/s4146…

We are thrilled to share that eLife - the journal has now published our "reviewed preprint" on how signaling from the gut to glia connects intestinal inflammation to sleep in #Drosophila! elifesciences.org/reviewed-prepr… HalbergLab J. Colombani & D.S. Andersen lab Lundbeckfonden Novo Nordisk Foundation Carlsbergfondet

Researchers have discovered a cell surface receptor that is essential for adipose #tissue responding properly to #insulin. When the receptor is inactivated, the response to insulin is insufficient. However, a researcher says that it may be possible to stimulate the receptor –