🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Dynactin-1 mediates rescue of impaired axonal transport due to reduced mitochondrial bioenergetics in amyotrophic lateral sclerosis motor neurons academic.oup.com/braincomms/adv…

Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy nature.com/articles/s4146…

A Review published in Nat Rev Neurology provides an overview of the current clinical and mechanistic understanding of stiff-person syndrome and discusses current and emerging therapeutic interventions.🔒 go.nature.com/48dEbVy

סטודנטים/יות ופוסט-דוקים/יות, ההרשמה לכנס בנוירוביולוגיה תאית ומולקולרית תיסגר בעוד שלושה ימים (3 בנובמבר)! יש עדיין סלוטים להרצאות ופוסטרים, אז מהרו להירשם (זה בחינם) ולהגיש תקציר (erez.weizmann.ac.il/apx/r/ws1/101/…). מחכים לראותכם במכון ויצמן ב 17 בנובמבר!

Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes: cell.com/neuron/fulltex…

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease: nature.com/articles/s4159…

Seeding-competent TDP-43 persists in human patient and mouse muscle | Science Translational Medicine science.org/doi/10.1126/sc…

PhD position: Join Perlson Lab to explore exosomal communication at the NMJ. Use cutting-edge techniques (omics, tagging, live imaging) in collaboration with a leading biotech company. High fellowship. Send CV to [email protected]

Chek out our new paper with an in-depth characterization of the AAV-C9ORF72 (G4C2)66 mouse model! actaneurocomms.biomedcentral.com/articles/10.11…

We are recruiting!! Please RT!

Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS: Cell Reports cell.com/cell-reports/f…

Grateful for the incredible team of bright minds driving our mission to better understand and fight ALS. Together, we make progress one step at a time

Excited to present our first paper on #sleep in #ALS in Science Translation Medicine (Science Translational Medicine), which highlights early-onset alterations in patients that are suggested to occur before #motor symptoms. science.org/doi/10.1126/sc…

G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation: cell.com/molecular-cell…

Check out our nature review with Tiannan Guo Guomics and Judith Steen Judith Steen on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI nature.com/articles/s4158…

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease: nature.com/articles/s4358…

Intramuscular Nerve Bundles Reflect TDP‐43 Pathology in the Medulla and Spinal Cord of ALS Patients pmc.ncbi.nlm.nih.gov/articles/PMC11…

Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures cell.com/neuron/fulltex…

Proteomics Analysis of the TDP- 43 Interactome in Cellular Models of ALS Pathogenesis onlinelibrary.wiley.com/doi/10.1111/jn…

Small-molecule dissolution of stress granules by redox modulation benefits ALS models nature.com/articles/s4158…