Goodbye Assistant Professor. Hello Associate Professor!

Ladies who lead in diversity, equity, and inclusivity!!! Congrats on a well deserved honor, Katherine King MDPhD ♥️🩸#ISEH2024

I've submitted my first ever tenure-track job application. Officially, I'm on tenure-track job market. My major interest is membrane protein structure & function. As a first-gen immigrant scientist, even being able to apply is a long way from a working-class family home in India.

1/8 ❄️🔬Excited to share our latest work published in Nature Communications! Led by Kaitlyn Abe and in colab with Tim Grant, we've discovered a simple, cost-effective way to mitigate sample damage at the air-water interface during grid preparation. #CryoEM rdcu.be/dSWfn

In our #RNA focus issue, we invited viewpoints from three groups on the controversy over PRC2-RNA interactions and asked how they might reconcile the findings on the topic. dlvr.it/TF7h5W dlvr.it/TF7h5h dlvr.it/TF7h6G

Ratan Tata ’59, B.Arch. ’62, the university’s most generous international donor and one of India's most respected business leaders and philanthropists, passed Oct. 9. We will remember his legacy of transformative giving to Cornell. news.cornell.edu/stories/2024/1…

MCDB's Kozik Honored by Microbiology Society | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…

Happy to share Elise and Tarah’s work on building a facile selection system to engineer E. coli leucyl synthetase for site-specific incorporation of many new noncanonical amino acids into proteins in eukaryotes, including ornithine and N-acetyl-methyllysine!

In Science Magazine - great collaborative work w/ AlbertW_lab & Rappsilber laboratory showing that bacterial RNA polymerase can thread nascent mRNA into the pioneering ribosome from two sides for higher translation initiation efficiency - target for antibiotics? eurekalert.org/news-releases/…

“We highlight the differences between human and mouse telomere biology that may contribute to discrepancies between human diseases and mouse models. Finally, we discuss recent efforts to generate new ‘humanized’ mouse models to better model human telomere biology.” 👇

Last week, we said farewell to the first postdoc of our lab, George Ghanim @AutomneNine who will start his own lab at Princeton in 2025. We are proud of you and thankful for all your contributions. Please watch out for exciting future opportunities from the Ghanim lab!

Our structural-guided insights contributed to the design of BBO-8520, a first-in-class dual inhibitor targeting both GTP-bound (ON) and GDP-bound (OFF) KRAS G12C. Excited to see this work now published in Cancer Discovery! @FredNatLab BridgeBio Pharma

New paper from the lab. We collaborated with the legendary Stuart Kornfeld lab to study the molecular mechanisms of how TMEM251/LYSET regulates the M6P pathway. Molecular Insights into the Regulation of GNPTAB by TMEM251 biorxiv.org/content/10.110…

Happy to share our new paper! 🎉 We show that #cGAS–#STING inflammation drives premature #aging in response to telomere shortening in #zebrafish. 🧬 Telomere-driven aging occurs in 2 stages: 1️⃣ Senescence, inflammaging, cancer 2️⃣ Genome instability, death tinyurl.com/34rhn67z

We are excited to share our collaborative work on the first-in-class RAS:PI3Kα breaker, BBO-10203, which has now been published online in Science Magazine ! 🔗 Read the full article here: science.org/doi/10.1126/sc… BridgeBio Oncology Therapeutics (BBOT) @FredNatLab Lawrence Livermore National Laboratory

This publication describes how BBO-10203 disrupts the RAS–PI3Kα interaction without impairing insulin signaling, resulting in broad antitumor activity across multiple cancer models. It also shows enhanced efficacy in combination with other targeted agents.

BBO-10203 is currently being evaluated in the Phase 1 BREAKER-101 trial (NCT06625775) in patients with HER2+ and HR+/HER2- breast cancer, KRAS mutant colorectal cancer, and KRAS mutant non-small cell lung cancer.

Happy to share our community note published in Nature Communications. In this 14-page article (34 authors from 9 countries), we discuss current practices in biomolecular phase separation and hope it will be useful to the biomolecular condensate community. nature.com/articles/s4146…

Tenure-track assistant professor position in neuroscience or physiology at University of Michigan LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…

MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) lsa.umich.edu/mcdb/news-even…