Glad to have Ginny as my mentor, it’s fun, collaborative and supportive. Excited for what’s yet to come ;)

Want an idea of what function a protein sequence has? Try out ProtNLM predictions on 310 copilot. Just ask "What is the function of [your favorite protein sequence here]"? Check it out at 310.ai/copilot. To learn more, watch this video: lnkd.in/g9Gy5Xex

My 2nd project is out in NatureStructMolBiol ! Following up the SUMO-RNF4 paper, from studying the replication-independent DPC repair, we identified TOPORS as a novel SUMO-targeted ubiquitin ligase, with SUMO1-binding preference. Thanks all in Niels Mailand Lab nature.com/articles/s4159…

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/…

Online now: Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions dlvr.it/T7ZBJM

Yesss!! It's out in Developmental Cell!🥳Check it out to see lots of new exciting data on the axonal ER and local translation compared to the pre-print. Thanks to the reviewers for their insights that helped improve this study. And many thanks to all involved, a real team effort!

Excited to share our new nature article reporting a novel cell polarity mechanism, mediated by contacts between the endoplasmic reticulum (ER) and plasma membrane (PM). Article: nature.com/articles/s4158…

We present: 'Multispectral live-cell imaging with uncompromised spatiotemporal resolution'. biorxiv.org/content/10.110… 1/16

Korsten, Kapitein et al. Utrecht University employ live cell imaging and expansion microscopy to show that nuclear polyQ aggregates associated with #HuntingtonDisease induce nuclear envelope (NE) blebbing and cause NE ruptures. hubs.la/Q02Lz9Hc0 #Disease #Membrane

VPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b rupress.org/jcb/article/22…

Sanzà, Klumperman et al. UMC Utrecht reveal a novel role of VPS41 in cellular trafficking, showing that it recruits biosynthetic LAMP carriers in a process dependent on the small GTPase Arl8b. hubs.la/Q035q9D-0 #Organelles #Trafficking

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS  🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy biorxiv.org/content/10.110…

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in Nature Methods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

To anyone who were excited for the release of SUM-PAINT, we now published a detailed protocol on to how replicate it in your hands! Check it out here: doi.org/10.1016/j.xpro… Thanks to Eduard Unterauer Eva-Maria Schentarra Jungmann Lab Eugenio F. Fornasiero

Excited to share our preprint, now available online on BioRxiv! biorxiv.org/content/10.110…. We uncovered the coupling of translation and secretion machineries at the #axonalER to promote local delivery of axonal transmembrane proteins (TMPs) to the plasma membrane.

I am happy to share our work on the role of the HOPS complex in APP trafficking and processing! 💫 Out now on bioRxiv: biorxiv.org/content/10.110…