Another unique angle of cell–cell mitochondrial trafficking: brain endothelial cell (BEC)-derived microvesicles transfer mitochondria to hypoxic BECs resulting in increased mitochondrial function. Devika S Manickam (she/her) Duquesne University sciencedirect.com/science/articl…

Here, the authors identified two populations of adipose-resident regulatory T cells. Interestingly, insulin signaling regulates the state transition between the two populations. #obesity #diabetes Nature Immunology nature.com/articles/s4159…

An important consideration when designing metabolic experiments using mice: housing density affects thermal biology largely due to "cuddling" (or lack thereof). NIDDK #metabolism #obesity #diabetes sciencedirect.com/science/articl…

Choosing an appropriate mouse model to investigate metabolic outcomes should not be overlooked: obesity-related outcomes of mice fed a high-fat diet is influenced by #genetics and sex (preprint). Auwerx Lab EPFL Life Sciences EPFL biorxiv.org/content/10.110…

Extracellular vesicles (EV) mediate communication between cells by transporting bioactive cargo that can modulate cell function and fate. Here, the authors show that patients with #metabolic syndrome have an altered EV profile compared to lean controls. frontiersin.org/article/10.338…

Long work week? Lacking sleep? Consider interval #training to combat sleep-loss-induced reductions in #glucose tolerance and mitochondrial respiratory function. Cool work Nick Saner @kaesser Stuart Phillips (he/him) David Bishop (🦋 also bluespotscience.bsky.social) Jon Bartlett sciencedirect.com/science/articl…

Exercise induced a methylation signature in skeletal muscle that was retained after 12 weeks of detraining. This is proposed to focus the transcriptional responsiveness to future bouts of exercise. Ferdinand von Walden Kevin Murach University of Kentucky #myotwitter academic.oup.com/function/artic…

Disrupting AMPK-glycogen binding leads to increased adiposity with concomitant increases in serum insulin levels and impaired glucose handling, but no changes in whole-body insulin sensitivity. Natalie Janzen Jamie Whitfield, PhD @JohnAHawley @NolanHoffmanLab mdpi.com/1258990

A nice review highlighting gene discovery studies as drivers to understanding the genetics behind obesity. Giles Yeo Icahn School of Medicine at Mount Sinai nature.com/articles/s4157…

Interesting work showing that cardiac-derived TGF-β1 can block #adipocyte cell growth, protect against high-fat diet induced weight gain, and promote an anti-inflammatory adipose environment. Molecular Metabolism Ohio State The Ohio State University College of Medicine sciencedirect.com/science/articl…

Check out our group's latest work: muscle-secreted neurturin promotes a fast-to-slow shift in myofiber properties, couples muscle oxidative capacity to slow motor neuron identity, and improves glucose homeostasis! Yildiz Jorge Lira Ruas Hedlund Laboratory cell.com/cell-metabolis…

HFD-fed mice have leaky mesenteric lymphatic vessels which promotes insulin resistance and visceral obesity. If lymphatic vessel integrity is improved, glucose tolerance and visceral adiposity follows suit. Enyuan Cao Natalie Trevaskis Matthew Watt nature.com/articles/s4225…

How does maternal high-fat diet affect BAT of offspring? Maternal #HFD alters the methylation status of key BAT-specific genes to disturb FAO and thermogenesis, and changes #BAT structure resulting in an overall 'whitening' of the BAT. frontiersin.org/article/10.338…

It's crazy how fast time passes! It feels like just yesterday that I started. Thank you to all of the Jorge Lira Ruas for the support thus far. Here's to another few years of great science 🍷🍸

Our group's latest work!

Fantastic opportunity with a 🔥 mentor

Congrats Serge Ducommun, Jorge Lira Ruas & team! Lots of cool data

Our latest paper just out @PNAS! We report the first biological function for the gene Zfp697/ZNF697, as a regulator of muscle regeneration. University of Michigan Medical School Institute for Heart and Brain Health Umich Pharmacology Karolinska Institutet #myotwitter pnas.org/doi/10.1073/pn…

🥑Almost as satisfying as finding the perfect avocado... My first PhD project is out! We show that KYNA’s metabolic benefits depend on its pulsatile increase in circulation—just like exercise-induced signals that improve metabolic health! Jorge Lira Ruas 🔗doi.org/10.1152/ajpend…

An unforgettable day! I’m deeply grateful for the amazing support and couldn’t have asked for a better team and supervisor Jorge Lira Ruas