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理研 高橋俊二先生、鄭博士、阪大 栗栖先生、宮ノ入先生らのグループとの共同研究の論文がpublishされました。高橋先生、鄭さんらのフェレドキシンが[4+2] cylcoadditionを触媒するというびっくりな発見に端を発した研究に携わらせていただきました。nature.com/articles/s4146…

We had an active conference at Nagoya Univ. Thank you all for the great talks and fruitful discussions! See you again at the next conference at Chiba in February 2025.

令和７(2025)年度 学術変革領域研究（A）（公募研究）の応募が始まりました。「予知生合成科学」では、応募上限額・件数ともに充実して公募研究を募集しております。本領域の発展に大きく貢献していただける方の積極的な応募をお待ちしております。mext.go.jp/a_menu/shinkou…

Kato Group (A03) has developed an artificial aldoxime dehydratase for nitrile synthesis based on the reconstitution strategy of myoglobin. pubs.acs.org/doi/full/10.10… ACS Catalysis #artificial_metalloenzyme #myoglobin #nitrile

We had a seminar for young researchers in Tomakomai, Hokkaido! It was a fantastic experience, with exciting presentations of the latest results and active discussions. Thank you all for making it a truly fruitful event! See you next year!

This work was featured on the inside back cover!

We had a wonderful 3rd Japanese-German Symposium on the Biosynthesis of Natural Products in Bonn. Thank you all for the great talks and fruitful discussions! See you again at the next conference in Japan.

#ChemBioChem In vivo and in vitro Reconstitution of Biosynthesis of N-Prenylated Phenazines Revealing Diverse Phenazine-Modifying Enzymes (Tomohisa Kuzuyama and co-workers) Kuzuyama_Lab #openaccess onlinelibrary.wiley.com/doi/10.1002/cb…

The Kuzuyama group (A01) has discovered unprecedented modification enzymes for natural phenazines. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

We enjoyed a fantastic 2nd Taiwan-Japan bilateral symposium on Natural Products Biosynthesis at the University of Tokyo. Many thanks for the insightful talks and engaging discussions! Looking forward to meeting everyone again at the next gathering.

The Terada group (A02) has published a paper presenting a machine learning-based method that predicts protein functional identity at a substrate-product level. doi.org/10.1016/j.csbj…

The Katsuyama group (A03) contributed to the MIBiG version 4.0. doi.org/10.1093/nar/gk…

The Terada group (A02) has published a paper with Profs. Mori and Abe tennen.f.u-tokyo.ac.jp/index-e.html. We computationally revealed the molecular mechanism by which LmbF and CcbF, which have similar sequences, catalyze different reactions on the same substrate. doi.org/10.1038/s41557…

第五回公開シンポジウムは2025年2/14-15に千葉⼤学（亥⿐キャンパス）薬学部創⽴120周年記念講堂で開催いたします。参加登録を受け付け中ですので、奮ってご参加ください！bio-4cast.skr.jp/241216-2/

Lab article: We have identified a pair of cyanobacterial diterpene synthases that produce a rare 6,6,7-tricyclic diterpene alcohol, deepening our understanding of the catalytic mechanisms of terpene cyclases. J. Am. Chem. Soc. pubs.acs.org/articlesonrequ…

The Kuzuyama group (A01), in collaboration with Prof. Jeroen S. Dickschat, has identified a pair of cyanobacterial terpene synthases to produce a rare 6,6,7-tricyclic diterpene alcohol, deepening our mechanistic understanding of terpene cyclases.J. Am. Chem. Soc. pubs.acs.org/doi/full/10.10…

The Kuzuyama (A01) & Terada (A02) groups revealed the significance of the cryptic amino group of the hydroquinone intermediate common to the biosynthesis of tetrahydroxynaphthalene-derived meroterpenoids such as furaquinocin and naphterpin #MyFirstChemSci pubs.rsc.org/en/content/art…

Lab article: We revealed the significance of the cryptic amino group of the quinone intermediate common to the biosynthesis of tetrahydroxynaphthalene-derived meroterpenoids such as furaquinocin/naphterpin. Chemical Science pubs.rsc.org/en/content/art…

The Katsuyama (A03) and Terada (A02) groups revealed the mechanism of ATP-dependent diazotase by combining structural biology, biochemistry and computational analysis. Angewandte Chemie #Enzyme #biosynthesis onlinelibrary.wiley.com/doi/10.1002/an…

The Terada group (A02) developed a novel terpene analysis approach that is high-speed, high-accuracy, and high-resolution by combining the Direct MaxFlux method with machine learning (ML) potentials. chemrxiv.org/engage/chemrxi… DOI:10.26434/chemrxiv-2025-md8k6