⚠️ Association Between Dosing And Combination Use Of Medications And Outcomes In HFrEF‼️: 📍 Data From The 🇸🇪 HF Registry Soc Esp Cardiología Asociación Cardiología Clínica SEC SACardiología Gregg Fonarow MD Steve Greene Muthu Vaduganathan Shelley Zieroth @DrNasrien Shahzeb Khan Robert Mentz, MD

Effects os Sacubitril/Valsartan vs Valsartan in renal function in 👥 HFpEF #PARAGON-HF #ACC22 Radcliffe Cardiology @ACCRME 👉Sacubitril/valsartan vs compared with valsartan 👉⤵️ the decline eGFR 👉⤵️clinically relevant kidney events among patients with HFpEF with and without T2DM

#ACC22 #JACC LBCT SimPub: A real-time, targeted, & tailored EHR-based alerting system for outpatients w/ #HFrEF led to significantly ⬆️ rates of GDMT at 30 days when compared w/ usual care. This low-cost intervention can be integrated into clinical care. bit.ly/3Ds8S9V

#PROMRT-HF 👉A personalized alert triggered via the HR during office visits led to significantly higher number of HFrEF patients on appropriate GDMT Giuseppe Galati Mamas A. Mamas Shelley Zieroth Radcliffe Cardiology #ACCRME #ACC22

📌The interplay between #SacubitrilValsartan, #HFpEF, diabetes & kidney function #CardioEd #CardioTwitter

Novel measures of LA structure and function, but not standard assessment by LAViMax, are associated with increased risk of incident #HF or death regardless of measures of LVfunction and #NT-proBNP #JACC #JACCHF JACC Journals jacc.org/doi/10.1016/j.… scottdavidsolomon Shelley Zieroth

Benefit of an accelerated up-titration schedule of #HFrEF 💊 European Society of Cardiology Journals, by @PSJhund Kieran Docherty Muthu Vaduganathan University of Glasgow Heart Failure Research Group and cols #CardioTwitter 🎯 At least 14 deaths and 47 HF 🏥/☠️ per 1000 patients treated might be prevented over the conventional approach ❗️

⚠️⚠️Accelerated and personalized 💊 for HFrEF 👉 accelerated up-titration schedule (Sequence 1a) & optimized ordering of treatment (1b-3) vs conventional approach (1) 👉⤵️ ☠️ and 🏥⤵️HF over the first 12m after starting 💊 via Muthu Vaduganathan & cia

Standard treatment guidance may not lead to the best patient outcomes in #HFrEF Alternative approaches could lead to a substantial reduction in lives lost and hospitalizations for worsening #HeartFailure academic.oup.com/eurheartj/adva… Muthu Vaduganathan Andrew J Sauer MD Javed Butler Sergio Kaiser MD, PhD, FACC, FESC 🇧🇷🇮🇱🇷🇴🇺🇦

⚠️accelerated up-titration schedule & optimized ordering of 💊 vs conventional up-titration schedules🪜 👉⤵️14☠️ 👉⤵️ x3️⃣ HF🏥/☠️CV per 1000 treated over the first 12 months after starting 💊 📂 doi.org/10.1093/eurhea…

EMPEROR-P vs DELIVER 📍iSGLT2 in HFpEF👥 👥Deliver vs Emperor-P👇👇 👉In-hospital or hospitalized within 30d (n=655) 👉HF w improved LVEF (n=1,156) 👉LVEF≥60% (n=1,892) Soc Esp Cardiología redGDPS Diabetes @ICyFA-SEMI SEMERGEN | Médicos de AP #SEMERGEN25

The EVALUATE-HF Trial In #HFrEF, serial changes in #NTproBNP correlate with changes in several key measures of cardiac structure and health status #cTnT changes correlate with changes in LV mass and sST2 with changes in health status onlinelibrary.wiley.com/doi/abs/10.100… Peder L. Myhre MD, PhD #EJHF

Steep declines in health status immediately before worsening of #HeartFailure Should we me measuring health status of people who contact us with worsening symptoms? ahajournals.org/doi/epdf/10.11… Dr. Deepak L. Bhatt

Dr Amar Puttanna 🎸 Muthu Vaduganathan Mamas A. Mamas Prof Kamlesh Khunti Dr. Deepak L. Bhatt Prof Chris P Gale Dr Anastasia Mihailidou FAHA FCSANZ FESC Harriette Van Spall, MD MPH 🇨🇦 Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 Claire Lawson European Society of Cardiology Prof Amitava Banerjee💙 KCCQ trajectory one of the best predictors of subsequent HF hospitalization, by far. It should be incorporated into clinical practice (EMR) and can be displayed at visits and alert if steep declines occur.

CHAMP-HF In routine care, changes in HFrEF 💊 were associated with significant ⬆️ in patients’ health status, suggesting that health status–based performance measures can quantify the benefits of titrating 💊 in patients with HFrEF doi.org/10.1016/j.jchf…

Optimizing the diagnostic utility of NT-proBNP for acute #HeartFailure in obesity and beyond onlinelibrary.wiley.com/doi/abs/10.100… European Society of Cardiology Journals European Society of Cardiology Mamas A. Mamas Wilfried Mullens HFAPresident Amina @JJheart_doc Andrew J Sauer MD Anju Bhardwaj MD FACC Steve Greene Muthu Vaduganathan

I asked one of these new AI tools (tome.app) to prepare me a presentation on duration of DAPT and the result is a sci-fi horror movie where the evil Dr Clopidogrel and his army of aspirin zombies prepare a plan to destroy the P2Y12 Receptor.