We offer an individual-level interpretation of polygenic score (PGS) transferability across genetic ancestries:
PGS accuracy varies individual-to-individual across the genetic-ancestry continuum, even in populations usually labeled as homogeneous.
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nature.com/articles/s4158…
Check out our latest paper in nature! We unveil the fascinating variation of individual polygenic scoring accuracy across the genetic ancestry continuum!
Our paper on estimating the expected number of African and European genealogical ancestors for a typical African American (born btwn 1960-1965) is out in this month's issue of GENETICS. Stay tuned for a thread and a series of excellent write-ups from GENETICS, USC, and Stanford.