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To regulate cellular processes in #syntheticbiology it is useful to bring 2 proteins into proximity, to reconstitute function, guide localization, transcription... We report that from a single 4 helical bundle several pairs can be made. Nature Communications nature.com/articles/s4146… 🧵

"De novo protein design has reached an inflection point, researchers say. AI-powered protein design is becoming very real and very usable, thanks to technological advances in the development of algorithms and the hardware that runs them." cen.acs.org/physical-chemi…

PUMPED that our paper introducing Light-Activated SpyLigation (#LASL) is now live at Nature Chemistry! We show bioactive proteins can be stably photo-assembled from split fragment pairs in solution, in biomaterials, and in living mammalian cells. nature.com/articles/s4155… (1/13)

De novo design of sequence-specific DNA binding proteins youtu.be/-H27Kv5duYA?t=… Design with Protein Lego Blocks youtu.be/-H27Kv5duYA?t=…

Happy to be part of this fantastic community (:

“We will be striking until we get a fair contract. Our priority has always been ensuring that science at UW is sustainable and inclusive, and that means fair pay so we can all afford rent, take care of our families, and stay in the careers we love.” ow.ly/1vTQ50OIiUt

Blueprinting expandable nanomaterials with standardized protein building blocks biorxiv.org/cgi/content/sh… #bioRxiv

Geometrically standardized features give LEGO blocks their ability to be intuitively assembled into structures. Here we show that designed proteins can be made to a similar standard, enabling useful features in nanomaterials such as scalable size: biorxiv.org/content/10.110…

Blueprinting expandable nanomaterials with standardized protein building blocks biorxiv.org/content/10.110…

We are happy to introduce to the world a new family of de novo designed heme enzymes! This work is the result of a wonderful collaboration between Institute for Protein Design and Green Research Group ! (1/n) pubs.acs.org/doi/10.1021/ja…

Join JUPITER and leverage AI for good! This research training program offers University of Washington undergrads the chance to use #AI and computational biology to tackle real-world challenges. Shape a better future in medicine, sustainability & technology. Apply by Aug 27. ipd.uw.edu/undergraduate-…

Excited to present our new bioRxiv on designed protein assemblies that can be allosterically switched between different oligomeric states, led by Arvind S Pillai and Abbas Idris Institute for Protein Design: biorxiv.org/content/10.110…

Super excited to finally see the publication of this great paper in nature; this was one of the first projects I got to work on in grad school! Home Depot inspired #ProteinDesign Institute for Protein Design Work led by Tim Huddy Ryan Kibler Yang and Jinwei Xu nature.com/articles/s4158…

Our new paper is up at Advanced Science @AdvSciNews: "Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies" 🔓: doi.org/10.1002/advs.2… ISCRM at UW📰: iscrm.uw.edu/protein-based-… UW Medicine📰: newsroom.uw.edu/news-releases/…

Super excited to share our paper “Design of amyloidogenic peptide traps” is out now! 🧠 nature.com/articles/s4158… Special thanks to Ewa Andrzejewska , Danny Sahtoe and David Baker

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

biggest achievement of my phd so far

Drugit: crowd-sourcing molecular design of non-peptidic VHL binders Nature Communications 1. This paper introduces Drugit, a novel small molecule design interface built into the Foldit citizen science game, enabling non-experts to design protein-targeting molecules using intuitive tools