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Excited to share AllofUsResearch program’s flagship genomics paper describing 245,388 clinical-grade genome sequences encompassing >1 billion genetic variants published today in nature nature.com/articles/s4158…

Very excited to have our study, the largest ever genetic investigation of circulating retinol now online at Nature Communications. We found evidence for novel biology and use these data to refine our understanding of retinol/retinoids on human health. 1/2 nature.com/articles/s4146…

AB-OpenLab is hiring!! First advertisement is out here imtech.res.in/recruitment/ro… Looking for individuals with passion for web technologies and game development. More positions for projects in Evolutionary biology, Machine Learning and AMR will be advertised soon. Please RT!

Excited to see our GWAS meta-analysis of NMR metabolic biomarkers in 136,000 participants from 33 datasets out in Nature nature.com/articles/s4158… after years of work by many people, esp. Savita Karthikeyan Clare Oliver-Williams Elias Allara Prof M Ala-Korpela Johannes Kettunen & Minna Karjalainen

Come work with us at PREDICT IBD! Kristine Allin and I are looking for a PhD student to combine the incredible Danish healthcare registry data with genomics. Great collaborators in UK, US, Nordics. Lovely industrial partners. It's time to personalise IBD care. 1/3

Congratulations to my student Teng Hiang on her first PhD preprint! It's about recessive associations in @GenesHealth , a cohort of >40k British South Asians. See her thread for an account and the paper here medrxiv.org/content/10.110….

Two Postdoc positions in my lab Human Technopole! Please RT! We have an Open Targets project in collaboration with Gosia Trynka lab. An ambitious project, with industry partnership to comprehensively understand regulators of B cell activation using CRISPR screens.

Recently out on #bioRxiv: our updated approach to identify regional variability in missense mutation intolerance (“constraint”) in protein-coding genes using the gnomAD database (Genome Aggregation Database). 1/n biorxiv.org/content/10.110…

Our #sepsis #eqtl paper is now published! Thank you Cell Genomics and our reviewers for a swift and smooth publication process cell.com/cell-genomics/…

RT this amazing opportunity to join two fantastic groups

Answers to the puzzle of aging lie partly in our telomeres. Out yesterday in Nature Genetics, the latest study led by AstraZeneca's Centre for Genomics Research used UK Biobank #genomics data to ask why some people have longer telomeres than others. nature.com/articles/s4158… 🧵

In our latest work, we explore the contribution of rare, typically inherited, damaging genetic variants to the risk of severe developmental disorders (DDs) and establish a major role for incompletely penetrant rare variation. Now out on medRxiv: medrxiv.org/content/10.110…

Interested in B cell biology, immunogenomics and autoimmunity? We are looking for an enthusiastic postdoc in my lab Human Technopole. Join us for a 4 years fully funded postdoc position. Outstanding scientific environment and infrastructure! Apply until 14 October 2024!

To those at #ASHG24, check out these presentations from our lab: @KlaudiaMWalter will be talking about rare variant associations and founder effects in British South Asians from @GenesHealth at 1.45pm on Friday (Session 81). 1/2

#ASHG2024 folks, check out the presentations from the Center for Genomics Research AstraZeneca.

Check this cool work done by Craig Glastonbury and colleagues using UK Biobank #MRI and #MachineLearning on #heart function #Genetics!

Interested in how non protein coding variants influence protein expression? Visit our poster today to learn more! #ASHG2024 #ASHG24

AstraZeneca's Centre for Genomics Research is hiring! Check it out if you are interested in leading an exceptional team of scientists who apply innovative machine learning approaches to large scale genomic and multi-omic data for drug discovery. lnkd.in/d54cpyvf

Excited to share our "mastzellen" paper! Mast read! How primitive is this mode of immune regulation by cell-intrinsic immunosteroids? 🤔 Well done Jhuma P. and Qiuchen Z., et al. 👏👏 👇 biorxiv.org/content/10.110…

📢 new preprint alert: So so excited to share our analysis on the impact of common and rare variants on single-cell gene expression in blood, using WGS and scRNA-seq data from nearly 2,000 individuals and 5.4m cells as part of TenK10K phase 1 🧬medrxiv.org/content/10.110… 🧵👇 (1/n)