Excited to share a new preprint out from the lab (biorxiv.org/content/10.110…) by 1st-author Brittany Hemmer , a newly minted PhD from the lab! A brief thread on what we found (1/n):

Proud of Amy and Nick, who review technical and theoretical gaps in timescales of dopamine fluctuations. We argue that DA fluctuations are hierarchical control signals, and “tonic” DA relays goal alignment across planning horizons and C-BG hierarchy. sciencedirect.com/science/articl…

I'm thrilled to share our work from Jonathan Weissman's Lab (sciencedirect.com/science/articl…). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

Neuro Current Ep. 38 features #JNeurosci authors discussing their paper on disrupted choice behaviors in a rat model of FASD. Listen to learn more about their methods. 🎧Listen: vist.ly/45w95 📺 Watch on demand: vist.ly/45w93

🚨New preprint alert🚨 We used closed-loop optogenetics to causally test the importance of inhibitory spike timing in network function and found that manipulating PV+ cell theta phase locking in the dentate gyrus can shift seizure susceptibility (both ways!)

Check out new work from our lab! We developed a new way to directly control the precise timing of interneurons during behavior and found that theta phase locking is a causal mediator of seizure susceptibility in both healthy and epileptic mice.

So excited for this! Can't wait to see everyone there!

That's a wrap! So many incredible talks at our Memory Hub Conference today! 🧠

OUT NOW! "Think Alike?": An Neuronline 🧠🔬 Podcast | "Diverging Ideas, Shared Goal". In this episode (8), Drs. Joe Zaki Joe Zaki & Zach Pennington join mentor Dr. Denise J. Cai, Ph.D. to reflect on journey of building a neuroscience lab from the ground up🎤 neuronline.sfn.org/professional-d…

It has been an immense honor to learn & grow with two of the greatest scientists I know: Zach & Joe Zaki 🧑‍🔬 Such a pleasure to mentor these two! Listen in on our conversation about mentorship, building trust and creating a safe space to disagree: neuronline.sfn.org/professional-d…

See you on the dance floor! Kay M Tye PhD Tristan Shuman

🚨 The paper from my postdoc in Johannes Gräff 's lab at EPFL is out! we show that memories can be switched on and off by simply changing the “packaging” of DNA in neurons through epigenetic editing. 🧬🧠🐭 nature.com/articles/s4158…

We're brewing up some Halloween fun in the Cai & Shuman Labs! ⚗️🎃 Just look at all the creativity everyone poured into their costumes! We have the coolest crew 👩‍🔬🧪

Stra8 links neuronal activity to inhibitory circuit protection in the adult mouse brain dlvr.it/TP3C0p

🧠 The Cai Lab will be at #SfN25! Be sure to stop by the poster sessions to check out Hailey Rosenblum's work on decision-making, Zach's work on stress & the amygdala, Zoé Christenson Wick, PhD's work on seizures, Alexa's work on cocaine seeking, and Sandra's work on context representations 🤓

🎉 Join us on Monday for the best party of the year! The Cai-Tye Collective is throwing a bash at #SfN25 and everyone is invited! 🎉 November 17, 9pm at Parq Nightclub in San Diego. See you all there!

If you are at SFN this week come to our SFN dance party! Monday night at Parq nightclub. Open to everyone. Denise J. Cai, Ph.D. Kay M Tye PhD and I are giving out VIP bracelets at SFN all weekend!

We're presenting Miniscope Zero, the first fully-wireless Miniscope, at #SfN25! Wireless power + data enable long-term neural recordings from multiple freely behaving animals. Miniscope Team Poster: Nov. 17, 1–5 pm, ZZ7, tinyurl.com/mhdfb67u Video: youtu.be/mIt15LA-rZI?si…

Hi! Come check my poster Monday morning on head fixed social interaction and spatial + social coding in the hippocampus along with other cool Giocomo lab posters🎊

Reunion with past and present Cai lab & Shuman lab members (and collaborators) at Society for Neuroscience (SfN). Spending time with you guys is easily the best part of my job Friedman Brain Institute.