Warm wishes to our US colleagues at PhoenixBio, clients, and collaborators in the USA! Thanksgiving reminds us that we can spread happiness around us and that we should look back at all the great memories and good people we connect with. Happy Thanksgiving Day!

New paper: “Development of an in vivo delivery system for #CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA”. In PXB-mouse®, AAV2/WJ11-Cas9 significantly suppressed HBcAg, HBsAg, and #HBV DNA along with cccDNA in the liver tissues phoenixbio.co.jp/contact/englis…

A novel human alanine aminotransferase 1 (hALT1) specific enzyme-linked immunosorbent assay (ELISA) is developed by PhoenixBio. The method is a valuable tool in #toxicity studies with humanized liver mice. #drugdevelopment #drugdiscovery

During NASH Summit dates, check out #NASH/ #NAFLD capabilities for in vivo and in vitro studies using our products: PXB-mouse® and PXB-cells®. #drugdiscovery #drugdevelopment

Thinking warmly of our clients and collaborators and wishing everyone a happy holiday season!

Pleased to share highlights of 2020 publications on PXB-mouse®. Two review papers provide a characterization of the model and summarize publications in various application areas. Find out highlights of PXB-mouse use in DMPK, Toxicity and Hepatitis Studies linkedin.com/feed/update/ur…

In 2020, the PXB-mouse® model and PXB-cells® were used to generate the results for 24 peer reviewed publications! This brings us to a total of 304 publications using PXB-mouse® and PXB-cells® and more are coming. We are looking forward to a productive 2021 ahead!

Our recent Open Access paper “Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency” describes the development of mouse model containing OTC-deficient hepatocytes with characteristics similar to OTCD patients.

Open access paper with characterization of PXB-cells® shows that PXB-cells® retain the benefits of fresh human hepatocytes, allow on demand supply from the same donor and show high activity of human specific enzymes and transporters: kmthepatech.com/robust-human-h…

The recently published Letter to Editor jstage.jst.go.jp/article/jbm/21… investigated intra- and extracellular lipid levels and lipoprotein profiles in PXB-cells® isolated at several time points post-transplantation of human hepatocytes into the PXB-mouse®.

Part I – PXB-cells in 2020 papers. In a few posts, we would like to review the 2020 publications with PXB-cells®. Hata, K. et al. describes lipoprotein profile and lipid metabolism of PXB-cells® Yamasaki, C. et al. is a summary characterizing PXB-cells®. phoenixbio.co.jp/en/news/human-…

Part II – PXB-cells in 2020 papers. Hepatitis B: Luo, J. et al. PLoS Pathog. 2020; 16(3): e1008459, Matsunaga, S. et al. iScience. 2020; 23(3): 100867, Chen, S.-W. et al. Sci Rep. 2020; 10(1):14349. More details: phoenixbio.co.jp/en/news/human-… #drugdiscovery #drugdevelopment #HBV

Part III – PXB-cells in 2020 papers. #Toxicity-related application of PXB-cells published in 2020. Learn more: phoenixbio.co.jp/en/news/human-… #drugdiscovery #drugdevelopment

#RareDiseaseDay takes place on the last day of February to raise awareness. PhoenixBio recently developed in vivo OTCD mouse model and in vitro model of OTCD based on hepatocytes isolated from those mice. More info: phoenixbio.co.jp/en/news/in-viv… Rare Disease Day

Two studies performed with the support of PhoenixBio’s Chimeric Mouse with Humanized Liver (CMHL) consortium from Vertex Pharmaceuticals and Takeda Pharmaceuticals are highlighted here. phoenixbio.co.jp/en/news/chimer… #drugdiscovery #drugdevelopment

Virtual #2021SOT and #ToxExpo organized by Society of Toxicology is approaching and will run until late March. This event will include the best of cutting-edge #toxicology, world-class researchers, expert service providers, and more. ToxExpo

During #2021SOT by Society of Toxicology Annual Meeting, we highlight several publications showing that the PXB-mouse® is the best available preclinical tool to evaluate human-specific #hepatotoxicity caused by drug candidates and other chemical reagents.

A hepatic vascular model for the assessment of #toxicity and drug induced liver injury (DILI) is discussed at #2021SOT by Society of Toxicology at “Liver: in vitro” session (Poster 2133 P126). ow.ly/TgYd50DTc8b #ToxExpo

As #2021SOT annual meeting by Society of Toxicology is getting to its final days, we would like to remind about PXB-mouse® and PXB-cells® in #toxicology applications. Learn more: ow.ly/mmWq50DWn0N, ow.ly/FkJi50DWn0M #ToxExpo

#2021SOT and #ToxExpo by Society of Toxicology is almost over, but we are always pleased to highlight the publications relevant to safety and #toxicity preclinical evaluations. Please check the news post on PhoenixBio website for a summary of three papers: phoenixbio.co.jp/en/news/toxici…