Now online in Cancer Discovery: Early Immune Remodeling Steers Clinical Response to Frontline Chemoimmunotherapy in Advanced Gastric Cancer - by Minae An, Arnav Mehta, Byung Hoon Min, You Jeong Heo, Seung Tae Kim, Sam Klempner, Jeeyun Lee MD et al. doi.org/10.1158/2159-8…

#ICYMI: Sequential #chemoimmunotherapy in #gastriccancer, by Minae An, Arnav Mehta, Byung Hoon Min, You Jeong Heo, Seung Tae Kim, Sam Klempner, Jeeyun Lee MD et al. bit.ly/48oMuMz Mass General Cancer Center @Broadinstitute #SamsungMedicalCenter SU2Cscience

Reporting association between whole-transcriptome sequencing and IHC. Reasonable concordance regarding HER2 and CLDN18.2 but not 100%. Need further analysis to clarify. OncoAlert #stomachcancer onlinelibrary.wiley.com/doi/full/10.11…

Was a pleasure to work on the #HPB #OG Scientific Committee for #ASCO24 Thanks to Sam Klempner for your leadership and to all for lively discussions and to ASCO for co-ordinating. Great to see Patrick Forde also.

Out online in parallel with Scott Kopetz #AACR24 presentation. Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer. Nataliya Uboha Rona Yaeger Tanios Bekaii-Saab, MD Cancer Discovery Marcia Cruz-Correa, MD, PhD aacrjournals.org/cancerdiscover…

Our latest paper in BJS questions the safety of organ-sparing approaches in oesophageal cancer. academic.oup.com/bjs/article/11… 1/12

GI Series: #UpperGi algorithm, w/ Sam Klempner to reiterate the current landscape: Full Discussion: - cancernetwork.com/treatment-algo… - Oncbrothers.com/upperGIalgo-20… - Also on the “Oncology Brothers” podcast #OncTwitter CancerNetwork® #MedTwitter #GISM

Big year for gastroesophageal at #ASCO24 ASCO ESOPEC plenary EA2174, ARMANI, and RENAISSANCE in the oral sessions. Karyn Goodman, MD, MS Nataliya Uboha Filippo Pietrantonio ECOG-ACRIN Cancer Research Group Lorenzo Ferri MD PhD Florian Lordick Yelena Y. Janjigian MD Kohei shitara Sara Lonardi Lizzy Smyth Raghav Sundar

Led by Sandra Ryeom from Stand Up To Cancer team: Stool protein mass spectrometry identifies biomarkers for the early detection of diffuse-type gastric cancer aacrjournals.org/cancerpreventi… Andy Chan David A. Drew Jeeyun Lee MD Jeremy L. Davis MD, FACS AACR Cancer Prevention Research

New from the May issue— Sequential chemoimmunotherapy in #gastriccancer, by minae an, Arnav Mehta, Byung Hoon Min, You Jeong Heo, Seung Tae Kim, Sam Klempner, Jeeyun Lee MD et al. bit.ly/3WFhTbt Mass General Cancer Center @Broadinstitute #SamsungMedicalCenter SU2Cscience

‼️ #ASCO24 simultaneous publication by Sam Klempner et al: PD-L1 Immunohistochemistry in Gastric Cancer: Comparison of Combined Positive Score and Tumor Area Positivity across 28-8, 22C3, and SP263 assays: brnw.ch/21wKljg

#ASCO24 plenary: ESOPEC 👏👏 👉🏼neoadj CROSS vs peri-op FLOT in pts with EAC 👉🏼221 in FLOT vs 217 CROSS arm 👉🏼 Median OS: 66mo FLOT vs 37mo CROSS 👉🏼 3-year OS 57.4% FLOT vs 50.7% (95% CI 43.5 – 57.5%) for CROSS (HR 0.70, 95% CI 0.53-0.92, p=0.012)

The June issue of Cancer Discovery is online! On the cover: Efficacy and Safety of Adagrasib + Cetuximab in Patients w/#KRAS G12C-Mutated Metastatic CRC by Nataliya Uboha Rona Yaeger Sam Klempner Scott Kopetz et al. Plus commentaries for #ASCO24 & much more: aacrjournals.org/cancerdiscover…

I am pleased to inform you that the primary result of JCOG1109 was published in the Lancet today. The neoadjuvant triplet chemotherapy would be the standard care for the locally advanced ESCC. Many thanks to everyone involved. thelancet.com/action/showPdf…

I'd like to call attn. to an outstanding professional development opportunity, the ASCO Leadership Development Program! I served as a Board liaison mentor & can't overemphasize the impact LDP can have on the career trajectory of participants. Apply here: brnw.ch/21wLj31

Congratulations to Harsh Singh and Dana-Farber team for getting this data out. CAPOX + Trastuzumab + Bevacizumab in frontline HER2+ gastroesophageal. Nature Communications James Cleary Ronan Kelly and others rdcu.be/dQvh4 -- full paper doi.org/10.1038/s41467…

Building one of the largest datasets of gastric cancer peritoneal metastases in the world, we unravel new biology of organotropism, the important role of the tumor microenvironment and novel biomarkers. Just published in Gastroenterology! Joseph J Zhao gastrojournal.org/article/S0016-…

Pleased to share final survival results of two phase 3 of zolbetuximab NEJM  which reinforce zolbetuxumab plus chemo as effective treatment option, though still need better treatment. More agents will be coming for CLDN18.2+ GC ESMO - Eur. Oncology OncoAlert #ESMO24 nejm.org/doi/full/10.10…