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How important circadian rhythm is for promoting our health: a study of ~89,000 @UK_biobank participants with 13 million hours of light sensors pnas.org/doi/epub/10.10… PNASNews Sean W Cain "Minimizing night light, maximizing day light, and keeping regular light–dark patterns

An amazing paper- a treat to read! Can't be more proud of former postdocs doing awesome science! Go Brian Muntean! pnas.org/doi/10.1073/pn…

I am thrilled to share the published version of our study on how neuropeptide signals regulate feeding in the hypothalamus! We imaged endogenous peptide signals in subcellular compartments during behavior. Below is an updated summary: rdcu.be/dZlI3

Our paper "GABAergic amacrine cells balance biased chromatic information in the mouse retina" is now published in Cell Reports cell.com/cell-reports/f…

Our paper, "The promise and peril of comparing fluorescence lifetime in biology revealed by simulations", is now on eLife - the journal: doi.org/10.7554/eLife.…. Hope readers will use our package to design and interpret FLIM experiments rigorously, and also give us feedback.

Here, we present a powerful, flexible tool that expands the reach of genetic screens to a wealth of previously inaccessible biological questions. We encourage our colleagues to reach out for protocols, reagents, etc. nature.com/articles/s4155…

Excited to share our latest study! 🧠✨ We reveal how non-direction-selective retinal ganglion cells encode motion beyond their receptive field, relaying the unconventional signals to the brain. A new insight into multimodal neurons in visual processing! pnas.org/doi/10.1073/pn…

Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. 1/3

We must learn to showcase the practical significance of basic research, demonstrating how seemingly arcane investigations yield transformative applications, writes @tonyzador. thetransmitter.org/outreach/how-t…

Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs. nature.com/articles/s4158…

Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward. pnas.org/doi/epub/10.10…

Our RUVBL2 paper is online published by Nature: trebuchet.public.springernature.app/get_content/8a…

Research from Daniel Kerschensteiner published in PNASNews, reveals how mice use vision to #hunt! 🐭🔬 Jenna Krizan, PhD, and colleagues revealed that some neurons in the superior colliculus inherit their motion-sensitive signaling patterns from the #retina. #eyes ophthalmology.wustl.edu/the-role-of-di…

1/ Why do late-stage cancer patients lose motivation & sink into apathy? 🔥Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu Sarah Starosta Marco Pignatelli Tobias Janowitz &team!🧵 🔗 doi.org/10.1126/scienc…

We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s4146…

Happy to share our recent work on a conductance that shapes substantially the output of rod photoreceptors. The role of the Ca2+-activated Cl- conductance in the membrane potential and light response of mouse rods jneurosci.org/content/early/…

ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on Addgene addgene nature.com/articles/s4159… Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators, Bernardo Sabatini Scott Kanoski Weiguang Weng 🦄💨✨ Bruce Herring

65 years after Lettvin’s bug detector neurons in the frog retina, we revisit how the retina drives behavior—from reflexes to prey capture to brain-state modulation New review with Anna Vlasits & Serena Riccitelli in Annual Review of Vision Science 👇 tinyurl.com/ymp3vs4d

Join us in congratulating professor Susan K. Dutcher, PhD, on her election to the National Academy of Sciences. Her groundbreaking research on cilia is unlocking insights into chronic disease and continues to elevate WashU Medicine’s legacy of scientific excellence and impact.