CAT-R, a scalable CRISPR/Cas9-based fluorescent reporter assay to study DNA DSB repair choice (—> small indels vs large dels). Novel HT tool to study DSB repair choice in chemical & genetic screens. Data for 400+ DDR genes and 21 DDR inhibitors! bmardin nature.com/articles/s4146…

Wondering how to effectively measure #ProteinTurnover in budding #yeast in a high throughput manner? Check out the new Khmelinskii lab khmelinskii lab method chapter to learn how to optimise your protein turnover screen 👩🏾‍🔬 👇👇 link.springer.com/protocol/10.10… #proteostasis #proteinbiology

great opportunities at IMB Mainz ! few hours left 😄

interesting discussion science.org/content/articl…

what it takes to validate the case of phase separation embopress.org/doi/full/10.15…

Starting the year off right: #throwbackthursday to the first IPP Mainz - PhD Network defenses from IMB Mainz groups in January 2023. Congratulations John Fung of the khmelinskii lab , Maria Beatriz from the Ulrich lab #PhDdefense #PhinisheD #PhDone

Defining protein degradation: How to build yeast libraries to dissect terminal degrons with fluorescent timers. By Kong, Reinbold, Knop lab, khmelinskii lab ISPT_ProteinTermini sciencedirect.com/science/articl…

check out our preprint on orphan quality control via C-degrons, by what seems to be a very promiscuous ubiquitin ligase! awesome work by edwin and susmitha shankar biorxiv.org/cgi/content/sh…

The Ketting lab at IMB & Falk lab Sebastian Falk from Max Perutz Labs Vienna identified a new enzyme called PUCH, which prevents the spread of parasitic DNA in our genomes. The findings may also reveal insights into how our bodies detect & fight bacteria and viruses. #piRNA #transposon

The Claudia 🕊 Keller Valsecchi lab together with Felicia Basilicata (Universitätsmedizin Mainz), Eric Marois (-) & Franjo Weissing (University of Groningen) discovered the master regulator that balances #Xchromosome gene expression between male & female #malaria #mosquitos. Read more: imb.de/about-imb/news…

11th IPP Symposium with our International PhD Programme students from Universität Mainz, Universitätsmedizin Mainz & IMB. What a great group of people 😍 If you would like to be a part of this group, take a look at the open projects in our current IPP call via imb.de/phd/projects

bizarre statement twtr.to/dfbJW by Moritz Schularick, president of the Kiel Institute (IfW Kiel) for the world economy, on the Nobel economics prize to Claudia Goldin Claudia Goldin how do you slap your mugshot into a statement about someone else's achievement? needy much?! 🥺

We are looking for new science colleagues in Generative and Synthetic Genomics! Senior Staff Scientist at Hinxton, Cambridgeshire; £52,152-£62,224 per annum sanger.wd3.myworkdayjobs.com/en-US/Wellcome… Postdoctoral Fellow at Hinxton, Cambridgeshire; £35,707- £44,712 p/a sanger.wd3.myworkdayjobs.com/en-US/Wellcome…

Most human proteins are N-terminally acetylated. Why? Here we find that a major role is shielding proteins from degradation. Specific E3 ubiquitin ligases recognize unacetylated protein termini. Impact on longevity and motility. European Research Council (ERC) nature.com/articles/s4146…

🚨 1 week left to apply to one of more than 25 #PhD projects offered in the winter call of our International #PhDprogramme! Find your project of interest within topics like #DNAdamage, #epigenetics, #RNAbiology, #ageingresearch, #proteostasis & more. ➡️imb.de/phd

Do you need AlphaFold multimer or molecular docking but don't know how to code? Try out Tamarind, a web-based tool for structural biology developed by Deniz Kavi, a previous Stanford undergraduate student in my lab. Currently free for academics :) tamarind.bio

Our Executive Director Prof. Helle Ulrich has been awarded an Advanced Grant from European Research Council (ERC) to fund her research on how a small regulatory protein called ubiquitin contributes to #DNArepair & the maintenance of #genome stability. Congrats Helle! 💐 ➡️imb.de/about-imb/news…