Protein isoform-centric therapeutics: expanding targets and increasing specificity tinyurl.com/2v5c3us8 Many genes encode multiple protein isoforms. This new review discusses targeting isoforms as a route to drugs with greater specificity and fewer adverse effects

Excited to share our new review discussing potential of targeting isoforms as a new route to drugs with greater specificity and fewer adverse effects! nature.com/articles/s4157… Published in Nature Reviews Drug Discovery Congrats Peter Kjer-Hansen Garvan Institute of Medical Research UNSW Biotechnology & Biomolecular Sciences EMBL Australia

🚨🚨🚨 Very excited to share our new preprint on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4: biorxiv.org/cgi/content/sh… Work led by Sophie Bonnal, with Simon Bajew & Rosa Martínez Corral. UPF Medicine and Life Sciences, Centre for Genomic Regulation (CRG). European Research Council (ERC). Short teaser👇1/7

The last part of my PhD research 🤓 is out!! If you are interested in RNA Biology -> Alternative Splicing and Epitranscriptomics + Evolution go have a look! A thread 🧵

Finally out nature.com/articles/s4158… the study (led by xavier salvatella & Méndez Lab) with the biophysical explanation for the profound effect of the microexon of CPEB4 as cause of autism, that we previously reported back in 2018 Parras Alberto Geschwind Lab @ UCLA Manuel Irimia HervasLab

🐟Our new paper "Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish" is out in eLife - the journal🐟 A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab Centre for Genomic Regulation (CRG) & UPF Medicine and Life Sciences elifesciences.org/reviewed-prepr… Thread👇

The job call is officially open. If you're interested, please apply through this link ASAP! 😃 mdc-berlin.de/career/jobs/po… Please RT! 🙏

Protein isoform-centric therapeutics: expanding targets and increasing specificity: nature.com/articles/s4157…

Thrilled to share my 1st PhD paper, exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬 #PhD #PhDthesis Finally published in Nature Communications: nature.com/articles/s4146… . With Manuel Irimia, Mara Dierssen, The Blencowe Lab @ U of T, Centre for Genomic Regulation (CRG), @icerca Details below: