My grandfather built motors that powered big machines. In a lab not so different from his workshop, my colleagues and I uncovered the assembly of the bacterial motor. Today, this discovery has been published in Nature Microbiology #MolecularNodes #Discovery nature.com/articles/s4156…

Leveraging AI to Explore Structural Contexts of Post-Translational Modifications in Drug Binding 1. This study explores the role of post-translational modifications (PTMs) in modulating drug binding, with a focus on understanding the structural consequences of PTMs using

📜 Our new preprint "Leveraging AI to Explore Structural Contexts of Post-Translational Modifications in Drug Binding" is out 👉🏻biorxiv.org/content/10.110… 💡 We explored the role of post-translational modifications (PTMs) in modulating drug binding, with a focus on understanding

New research in Science represents a notable step forward in designing enzymes from scratch. With a new approach, researchers designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, analogous to what many proteases do when breaking apart proteins.

Join Kirill Medvedev at poster B28 for the latest computational biophysics research from UT Southwestern Medical Center. Interested in UTSW? Visit us online bit.ly/4htNvID. Biophysical Society #bps2025.

Excited to be a part of UT Southwestern Medical Center team The Department of Biophysics at UT Southwestern Biophysical Society #bps2025

We trained a genomic language model on all observed evolution, which we are calling Evo 2. The model achieves an unprecedented breadth in capabilities, enabling prediction and design tasks from molecular to genome scale and across all three domains of life.

Who's that molecule? It’s Pikachurin ⚡ Researchers in a 2023 @SciSignal study solved the structure of Pikachurin, an extracellular protein that plays an essential role in vision. Learn more: scim.ag/41dTWIP #NationalPokémonDay

Way to go! This month, two journals released data from their own experiments that suggest that offering payments of around US$250 to researchers who review manuscripts speeds up the process, without affecting the quality of reviews nature.com/articles/d4158…

How a junk-food splurge can change your brain activity "Five days of indulging in chocolate bars, crisps and other junk foods can lead to lingering changes in brain activity similar to those seen in people who have type 2 diabetes" nature.com/articles/d4158…

We used AI to study how post-translational modifications (PTMs) affect drug binding and protein structure. Using AF3, RFAA and Chai-1, we generated > 14,000 models with > 6,000 of ligand-related PTMs. Paper is out in Journal of Cheminformatics rdcu.be/ekFlo #drugdiscovery #AI

Thrilled to share that I'll be joining UCF UCF Computer Science as an Assistant Professor. Medvedev Lab (medvedev-lab.cs.ucf.edu) will open in August 2025. Our work will address critical biological questions in Structural and Cancer Biology. Stay tuned 😉

I'm developing a new protein vault technology, so it is helpful to keep notes on the remarkable biological characteristics of vaults. For those who are curious about these mysterious organelles, I've put some of my notes on my website :) Link: logancollinsblog.com/2025/06/03/key…

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Computer algorithms have designed highly efficient synthetic enzymes from scratch go.nature.com/4jXfAZm

A periodic reminder to leave behind simplistic & naive notions.

DrugDomain v2.0 is out - drugdomain.cs.ucf.edu The database reports the interactions of structural protein domains with a wide array of small organic (including drugs) and inorganic compounds, covering the full breadth of the Protein Data Bank. doi.org/10.1101/2025.0…

I tried... 😅

Very excited to be a part of this collaboration