Exemplary work from the IRIS collaboration! Executing multicenter trials can be challenging in many respects, pre-planned meta analyses are an elegant and scientific equally good alternative Charles Majoie Urs Martin Fischer Kilian Treurniet Manon Kappelhof

1/ Time for a controversial topic based on true and frequent stories... This one is for all people managing acute stroke #NeuroTwitter #MedTwitter #Tweetorial

#ESOC2023 has officially started and with a strong start 💪#IRIS collaboration of major IVT+MT trials has showed superiority of IVT+MT vs MT alone within 2h15min window 🎯 European Stroke Org Johannes Kaesmacher Manon Kappelhof Kilian Treurniet

If you invite Johannes Kaesmacher you get stellar RCT data, incredible visualization and directly clinically applicable advice. #ESOC2023 Stroke Research Center Bern

The #ELAN #RCT suggests that starting #anticoagulation for atrial fibrillation early after an ischemic #stroke may be as safe and better at preventing further events than delaying. The results of #ELAN are presented now at #ESOC2023 & published today in the NEJM 👇👏

In the #ENRICH #trial, 300 #ICH patients were randomised to minimally invasive surgery vs. medical care <24h after onset Today @ #ESOC2023 the results are presented👇 The 1st #RCT in #ICH to show a positive effect of early minimal invasive surgery on functional outcome @ 6M 👏

New data from the #IRIS collaboration were presented at #ESOC2023 by Johannes Kaesmacher and Jasper Daems, indicating how time to treatment can impact the efficacy of #Thrombolysis prior to #EVT (as compared to direct EVT) European Stroke Org #Stroke neuronewsinternational.com/iris-data-shed…

The registration for the European Stroke Org ESMINT Society ESNR Stroke Winter School 2024 is now open! The aim of the teaching course is to unite stroke physicians and neuroradiologists in order to enhance interdisciplinary management of stroke patients. strokewinterschool.com/index.php/menu…

#AllEyesOnIris meta-analysis on #bridging IVT on top of MT for LVO patients at CSCs out in The Lancet today! No non-inferiority of direct #MT, but reasonable if expected benefit of IVT low Johannes Kaesmacher Urs Martin Fischer Manon Kappelhof Thomas Meinel sciencedirect.com/science/articl…

🧠 New insights in stroke #treatment! A meta-analysis study co-led by Charles Majoie and Yvo Roos, published late last night in The Lancet, sheds light on combining treatments for acute ischemic stroke. amsterdamumc.org/en/research/in…

Should ischemic stroke patients eligible for EVT also receive IVT if they present directly to an EVT-capable center? Our independent patient data meta-analysis published today @theLancet on behalf of IRIS has some answers🧵⬇️#allEyesOnIRIS authors.elsevier.com/c/1hes5_3CjG8W… #stroke

Our #alleyesonIRIS IPDMA comparing EVT with prior IVT to direct EVT in anterior LVO stroke patients directly presenting at an EVT center is out now! See the thread below by our brilliant PhD student Fabiano for a summary and link to the manuscript! Let us know your thoughts

An international study published in The Lancet and co-led by Jan Gralla & Urs Fischer (Urs Martin Fischer) of Universität Bern provides important insights into the combination of treatments for acute ischemic #stroke. See: sciencedirect.com/science/articl… Insel Gruppe

Intravenous thrombolysis is recommended before endovascular treatment, but its value has been questioned. A recent study assesses non-inferiority of endovascular treatment alone versus intravenous thrombolysis plus endovascular treatment. buff.ly/3t1WEnu

Time to Treatment with Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis, presented today at #ISC24, is free to read online from JAMA. ja.ma/4bsRl28

Study findings indicate that the benefit associated with intravenous thrombolysis prior to thrombectomy was time dependent and lessened with longer times between symptom onset and expected administration of intravenous thrombolysis. #ISC24 ja.ma/4bqFD87

Time matteres for IVT prior to thrombectomy! Great presentation of Johannes Kaesmacher from Stroke Research Center Bern at ISC and simultaneous publication in JAMA #alleyesoniris Fabiano Manon Kappelhof Kilian Treurniet Urs Martin Fischer jamanetwork.com/journals/jama/…

🚨 NEW data from the #IRIS collaboration 🚨 Benefit of IVT+EVT over EVT-only is time dependent and IVT has the strongest effect if given within 2h20min #GoLytics #AllEyesOnIRIS 👀 Very importand data! Johannes Kaesmacher Fabiano Manon Kappelhof Kilian Treurniet Urs Martin Fischer