🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

It’s alive on BioRxiv! Super excited to present our paper on CRISPRi-based screens in 3D neuron-astrocyte-microglia co-culture (iAssembloids) to examine neuron-glia interactions. Description of this work in the thread below! Too many words! (1/8) biorxiv.org/content/10.110…

Stress induces behavioral abnormalities by increasing expression of phagocytic receptor, MERTK, in astrocytes to promote synapse phagocytosis: Immunity cell.com/immunity/fullt…

IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinflammation in glaucoma and brain tauopathy: Cell Reports cell.com/cell-reports/f…

John Lukens Is chronic social defeat like getting your grants unfunded over and over again?

Human microglia maturation is underpinned by specific gene regulatory networks: Immunity cell.com/immunity/fullt…

This is truly a tour de force I could not have been more proud to contribute to! Check out this truly immense and impressive work put out by the soon-to-be Dr. Littleton!

biorxiv.org/content/10.110… Super happy to announce the culmination of a super fun and interesting project! TL;DR we observed an inverse relationship between the metabolic profile and strength of the circadian rhythms in cancer cells; which could aid in therapeutic interventions.

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells biorxiv.org/cgi/content/sh… #bioRxiv

My functional validation of a causal variant at the FAIM2 obesity GWAS locus is out today in Cell Genomics! (1/4) cell.com/cell-genomics/…

We found that the rs7132908 obesity risk allele can switch an enhancer→repressor, modify nearby gene expression with FAIM2 consistently downregulated in multiple cell types, and decrease appetite-regulating neurons produced by ESC differentiation (2/4)

Our hypothesis is that FAIM2 is required for normal appetite-suppressing neuron development/survival during childhood and decreased FAIM2 contributes to increased obesity risk at a young age (3/4)

I’m so proud of this challenging work and must thank many contributors including @STRUANGRANT Matt Pahl Alessandra Chesi Kieona Cook and amazing core facilities at Penn Medicine and CHOP Research (4/4)

Microglia transplantation therapy for treating neurodegenerative conditions doi.org/10.1016/j.neur… doi.org/10.1016/j.neur… Neuron

Finally out! Check out our new paper in Nature Communication 10.1038/s41467-024-49596-0. In this new study, we established that microglia make their own TGF-β1 ligand to maintain brain homeostasis and cognitive function via autocrine signaling mechanism at a single-cell level!

🚨 Registration is LIVE for our FIFTH annual Black In Neuro Week, happening this July 29-August 4th! We’ll have seven days packed with FREE programming that’s open to all. 🥰🧠 Register today!! ➡️ blackinneuro47.wildapricot.org/event-5771083

Microglia are the brain’s resident immune cells, and in neurodegenerative diseases they become dysfunctional. @Fchrisbennett is studying ways to re-engineer microglia so they reduce or prevent neurodegenerative disease instead of contributing to it 📸 Sonia Lombroso UPenn Pharmacology Graduate Group

Super Exciting Opportunity to do Super Exciting Work!

Viewpoint from authors at Boston University School of Public Health examines how the outcome of the 2024 US presidential election could affect the future of medicine and public health. ja.ma/40rEs5j

At times like today, I am reminded why the work we do to make higher education equitable for minoritized scientists is vital. Over the next 4 years, we will see higher education face one of its most critical challenges due to an expansion of the anti-DEI laws as US colleges