ANGPTL-3 inhibition w/ the human monoclonal antibody, SHR-1918, ↘️ serum LDL-C by 22% to 30%, as well as triglyceride levels by 52% to 63%, in pts at moderate or higher risk of #ASCVD, w/ the effect being dose & frequency dependent. More: bit.ly/4l9jxfn #ACC25 #JACC

#STROKE: FTY720 may enhance cholesterol recycling via TREM2 in microglia, fueling oligodendrocytes & remyelination — offering a novel therapeutic target for ischemic white matter damage. #AHAJournals ahajrnls.org/4lIDDx7

A paradigm shift in severe aortic stenosis (AS) care is now here. SAPIEN 3 TAVR is the first and only valve indicated for patients with asymptomatic severe AS. ⚠ Important Safety Info: bit.ly/3AYIpUc

Trump terminated $1.8B in science funding in 40 days. A loss of ~$4.6B in future economic activity. Means a higher fraction of new discoveries will be overseas. We'll be buying our future drugs from other countries...and, oh - they'll have tariffs on them. jamanetwork.com/journals/jama/…

Discovery of KCNQ5's role in PVAT-VSMC signaling reveals new ways to protect vascular health and fight hypertension! Uni Greifswald ahajrnls.org/43AbobS

Two excellent WIP presentations from Drs. Gaganpreet Kaur and Greg Gipson representing Heart and Vascular Institute research across the translational spectrum.

Excited to report this important collaboration which we hope helps us understand ICI-myocarditis better, published in #EHJ today! Along with the great DrJE-Salem! EHJ Editor-in-Chief Johann Bauersachs #CardioOnc UCSF Cardiology UCSF Helen Diller Family Comprehensive Cancer Ctr academic.oup.com/eurheartj/adva…

Our group has been interested in understanding the clinical features of ICI-myocarditis ever since we described the first 2 patients with ICI-myocarditis in NEJM in 2016 along with #DougJohnson BalkoResearchLab & others!

Honored to be an HHMI FHS! Grateful to colleagues who push me to think deeply, and students whose curiosity & energy make the lab a joy. My grad advisor said in genetic screens, you don’t get what you want—you get what you deserve. Hope we are deserving! hhmi.org/programs/freem…

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production Science Immunology Poltorak Lab science.org/doi/10.1126/sc…

This should be required reading by all graduate students and postdocs | A brief guide to statistical analysis of grouped data in preclinical research nature.com/articles/s4225…

Exciting new clinical progress in stem cell derived therapies ⁦University Health Network⁩ Ajmera Transplant Centre UHN⁩ Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | New England Journal of Medicine nejm.org/doi/full/10.10…

Dear Son, Watch these 12 movies before it’s late: 👇

We can't wait for the #KISymposium on June 27th! Our 2nd session of panels will feature the KI's Laurie Boyer, Dane Wittrup & Jeremiah Johnson, & Daša Lipovšek of Aktis Oncology. Join us for a deep dive into the world of antibody drug conjugates! mit-ki.org/4jdKWuH

Can’t wait to join everyone at @EndovascularNY in a couple short months. Discussion of aortic cases is second to none. (And the prizes aren’t bad either). Would highly recommend vascular trainees reserve a spot and secure a scholarship ASAP! FutureVascSurgeons VESS VSIG

Pleased to share this illustrative case report published in Pulmonary Circulation, with our colleagues from Hangzhou, further supporting our recent work on FLNA and #PAH onlinelibrary.wiley.com/doi/10.1002/pu… publications.ersnet.org/content/erj/65… Pulmotension InsermU999 Société de Pneumologie de Langue Française (SPLF) HTaPFrance

In the latest issue! High-speed mapping of whole-mouse peripheral nerves at subcellular resolution dlvr.it/TLvrFh

What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope! Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals. Read the paper here: science.org/doi/10.1126/sc… (1/9)

#VasoplegiaSyndrome is a serious complication after cardiac surgery with high morbidity & mortality. Pathophysiological pathways are known, but future research is required for a better definition & standardizing outcomes. bit.ly/4ltgrTd #JACCHF #cvSurg Michael Givertz

In person symposium registration: ❤️‍🔥❤️🩺 i3.mgh.harvard.edu/2025symposium/ ❤️‍🔥❤️🩺 Spectacular lineup of speakers -- so looking forward to discussing how ❤️‍🔥inflammation imaging ❤️‍🔥can propel basic research, translation and clinical trials! ❤️‍🔥❤️🩺 October 23 2025 All are invited!!