You wanted to delete one locus, and you got two FUNCTIONAL ones (duplication AND inversion) plus extra "bonus" (downstream large size integration). Surprise Surprise! biorxiv.org/content/10.110…

Fantastic work & presentation by Lara Merino from the Karolinska Institutet MSc program in biomedicine SciLifeLab. Lara & Keyi found an #CRISPR off-target. Unlike, prior assumptions Cas9 is NOT responsible for it ... stay tuned, we will reveal the culprit.

Our recent paper on tRNA evolution in birds is part of a special section in GBE (Genome Biology and Evolution) on synonymous mutations.😃 academic.oup.com/gbe/article/13… Here is the link to the tRNA story with Keyi, Alexander Suh 서상재 & Claudia Kutter 🧬 academic.oup.com/gbe/article/13… #ornithology #genomics

Nanoengineered DNA origami with repurposed TOP1 inhibitors targeting myeloid cells for the mitigation of neuroinflammation biorxiv.org/content/10.110…

The artwork version of our manuscript: "Genome size reduction and transposon activity impact tRNA gene diversity while ensuring translational stability in birds" academic.oup.com/gbe/article/13… Claudia Kutter, Keyi, Alexander Suh 서상재

Nice to see our study published in Gut Journal. Fantastic work by Jonas N. Søndergaard Christian Sommerauer @IonutAtanasoai Laura Hinte Keyi #GuiliaGuiducci #LarsBrautigam @AouadiLab Lovorka Stojic and #IsabelBarragan.

At first we couldn’t explain what was going on in our deletion clones. Thanks to @samplix Xdrop Oxford Nanopore LRS, Keyi Lara Merino solved the puzzle …and recently discovered more. Please stay tuned.

4 abstract submissions, 4 selected presenters! Well done #KutterLab! Keyi Christian Sommerauer Carlos Gallardo Dodd #RiccardoMosca presenting #CRISPR-on/off-targetig, #anticodon-codon-balance, #GeneRegulation in LiverDisease and #RNA-binding-proteins

Very proud to have contributed to this amazing work! Check it out to learn about unexpected CRISPR-Cas9 outcomes and how to detect them!

If you are struggling with some mysterious observation in Cas9 edited cell, check our work on unexpected on-target effect using a super cool tool in early release! Big thanks to everyone contributing to the work!

BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”

Wonderful to see our review tinyurl.com/4un6xbmv in press AJP-Cell Physiology. It's about the astonishing roles of #ncRNAs and RNA-binding proteins #RBPs in liver physiology and metabolic diseases. Great work by PhDstudent Christian Sommerauer

After acceptance earlier this year, it is nice to see our study in print Gut Journal

Be careful with cells you work on. Some of them can sneakly and secretely lose an important piece in their genome to outcompete their peers... Big thanks to everyone contributing to this work!

Very excited to have the full story from my master thesis out! Keep an eye on how your cell lines behave when using CRISPR-Cas9... Thanks to Claudia Kutter and Keyi for the opportunity and to all authors for their work!

Congratulations to the talented Keyi for absolutely acing her PhD defence today, it's been a pleasure co-supervising you! 😄 Looking forward to seeing what adventures await 🎉

Amazing highlight of a PhD journey: Keyi final task as respondent at her PhD defence! Congratulations Dr Geng! One of the best PhD students one can wish for! It has been such a pleasure and privilege to supervise you! Looking forward to your bright future!

Happy to present our latest preprint biorxiv.org/content/10.110…

Work by Keyi Claudia Kutter Karolinska Institutet SciLifeLab reveals genome fragility causing 10q23.31 deletion, incl. PTEN, in HAP1 cells, changing profiles resembling those of cancer patients. Stress elevates frequencies, affecting cell readouts bit.ly/3utYDSk

Wonderful to see Keyi's study published x.com/LSAjournal/sta…