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#PARP Technology Update Thread 🎉 1/ Back in 2015, we published a review Molecular Cell! Since then, technology has advanced at lightning speed!🌩️ Time for an update, right? With Morgan Dasovich from our lab, we've got you covered! authors.elsevier.com/a/1g%7Ev63vVUP… Let's dive in! 🌊

Regulation of Biomolecular Condensates by Poly(ADP-ribose), excited for our review by Kevin Rhine, Hana Odeh & Myong Lab to be out! pubs.acs.org/doi/10.1021/ac…

🤯 Ever heard of a third nucleic acid, with therapeutic potential? Our lab's new PNASNews paper uncovers new properties of Poly(ADP-ribose) (PAR), stiffer than DNA & RNA, with unique protein interactions! Dive in: pnas.org/doi/10.1073/pn… #PARP #Cancer #Neurodegeneration (1/9)

In a recent brilliant review in Chemical Reviews, the authors including ShorterLab discuss the role of Poly(ADP-ribose) (PAR) in the lifecycle of #condensates and how targeting PARylation may be an option for treating neurodegenerative disorders. Check it out: pubs.acs.org/doi/10.1021/ac…

Our work mapping the RBP interactome is now available as a preprint on bioRxiv! We show that many RBPs act as conduits or bridges between different stages of the RNA life-cycle. Check the full paper out below~ Katie Rothamel Gene Yeo’s Lab at UC San Diego biorxiv.org/content/10.110…

In collaboration with Jovanovic Lab, we’ve generated a comprehensive RNA-aware RBP-centric protein-protein interaction map by combining IP-MS with size exclusion chromatography (SEC-MS). biorxiv.org/content/10.110…

It was great to organize and guest edit the latest issue of Chemical Reviews on Phase Separation with Sua Myong Myong Lab: pubs.acs.org/toc/chreay/123…

La Jolla Aging Meeting 2024 Featuring @Larallbb, Massenet Jimmy, Minhoo Kim, Ceda Stamenkovic, Xiao Tian, Kevin Rhine (Gene Yeo’s Lab at UC San Diego), Courtney Glavis-Bloom, Francesco Della Valle, Tobias Schmidt, Stephanie Heimler, keynote by Peter Adams🇪🇺🇺🇳 & guest talk by Vera Gorbunova

The daughter of a scientist and a supporter of diversity in STEM, Harris’s prospects have stirred optimism among scientists. go.nature.com/3SiPuFg

Excited to share our work in collaboration with Kevin Corbett on detecting protein-RNA interactions with RNA-base editing in situ in fixed cells and primary tissues. Congratulations Lisa Liang and Tao in our lab! Thank you Chan Zuckerberg Initiative for the support! nature.com/articles/s4146…

I had a great time presenting and meeting other phase separation scientists at the Keystone Symposium in Breckenridge! Paper will be accepted soon hopefully 🤞

Engineered NLS-chimera downregulates expression of aggregation-prone endogenous FUS nature.com/articles/s4146…

🚨Excited to share another paper in Molecular Cell!🚨 In collab w/ Columbia University’s Marko Jonvanoic, Lena Street, & @HoustonMethodist’s Kris Brannan, we mapped RNA-aware, RBP-centric protein-protein interactions (PPIs) across the mRNA life cycle in human cells! cell.com/molecular-cell…

Chronic stress antagonizes formation of Stress Granules biorxiv.org/cgi/content/sh… #biorxiv_cellbio

G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation: cell.com/molecular-cell…

Excited to share the preprint of the last portion of my grad work with Gemechu and Myong Lab! We show that the RNA helicase DDX6 can tune the nucleation and fluidity of FUS condensates, including ALS-linked variants. Read more here: papers.ssrn.com/sol3/papers.cf…