#ScienceSaturday Can dietary nutrients help the immune system kill #cancer cells? In this study, researchers screened 255 circulating nutrients for the ability to enhance T cell activity and found that the long-chain fatty acid TVA (Trans-vaccenic acid) could enhance the

I am so excited that Emily Gentry (@gentrylab) paper on reverse metabolomics to discover molecules is published, a project started in 2018. She found many new lipids and bile acids in humans. nature.com/articles/s4158… (online rdcu.be/dsPUg) What is reverse metabolomics?

Basophil/eosinophil IL-4 acts on granulocyte-monocyte progenitors to promote immunosuppressive myelopoiesis in cancer. Dupilumab in RR-NSCLC w/ PD-1 blockade ⬇️ monocytes, ⬆️ CD8 TILs, and 1/6 patients had near-complete clinical response Miriam Merad, MD, PhD nature.com/articles/s4158…

We are happy to announce our newest publication in Science Immunology! In this article headed by Dr. Stephanie Jost, we dive into the role of the NKG2/HLA-E axis in antigen-specific NK cells science.org/doi/10.1126/sc…

scRNA-seq and CRISPR probe of NK cell interaction w/ broad panel of blood cancer types reveal mechanisms of NK cell resistance & potential immunotherapy targets Immunity Mustjoki Mitsiades Olli Dufva @DrSGandalf Jani Huuhtanen cell.com/immunity/fullt…

In situ vaccination approach that combines radiation and intratumoral injection of a tumor-specific antibody and IL-2 (3xTx) elicits CD8+ T cell immunity supported by NK cell-mediated regulatory T cell antagonism in non-targeted tumors Cell Reports cell.com/cell-reports/f…

We are very excited to present the development of Zman-seq (“Zman”, Hebrew for “time”), the 1st technology that measures single-cell transcriptomes and physical time in vivo, led by Daniel Kirschenbaum, Ken Xie, Florian Ingelfinger, Assaf Weiner sciencedirect.com/science/articl…. (1/19)

Online now: Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection dlvr.it/T0j2c5

Proud and excited to finally share the entirety of our work, newly online in Science Magazine! Here, we reveal the deterministic reprogramming of pro-angiogenic neutrophils in tumours! #ThePowerOfMany #ScienceResearch science.org/doi/10.1126/sc… Read on to learn more! 🧵(1/16)

#antibody-dependent cellular cytotoxicity (ADCC) capacity of #NKcell not impacted by NK cell education, but KIR2DS1 & KIR2DL1-C245 receptors exhibit dominant role in restricting ADCC from Mattias Carlsten Karolinska Institutet #ReadTheJI 👉 ow.ly/Oz3l50QIp21

Why are ~10% of humans left-handed? (🙋‍♂️) Exome-wide association study of rare variants in UK Biobank identified alleles of the beta-tubulin gene TUBB4B. Could be related to cilia function, which has been linked to other left-right asymmetries. nature.com/articles/s4146…

Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING. Read the full article by UMich Imm Grad Prog U-M Rogel Cancer Center Blake Heath, Leo Lei, DDS, PhD & others in Cell Reports #AACR24 hubs.li/Q02rxfMQ0

Cryopreservation protocols optimized for T cells kill ~75% of NK cells w/in 24 h of thaw due to leakage of GzmB from vesicles. This is prevented by IL15/IL-18 pretreatment to ⬆️antiapoptotic genes & deplete gzmB containing granules [Berjis & Sheppard] nature.com/articles/s4146…

Tumor-associated NK cells induce myeloid-derived suppressor cells to suppress antitumor T cell responses Science Translational Medicine Congrats, Neo Shi Yong & Lundqvist Lab science.org/doi/10.1126/sc…

Expression of Ly49A alone on a H-2Dd background restored missing-self target cell rejection, NK cell licensing, and NK cell KLRG1 expression, therefore a single inhibitory Ly49 receptor is sufficient to license NK cells Sytse Piersma #Yokoyama doi.org/10.1101/2024.0…

NK cell reactivity decreases rapidly upon activation by tumor cells, independently of immune checkpoints Science Advances Thierry Walzer science.org/doi/10.1126/sc…

Study showing that some immune cells (TH17) are at the origin of cancers - An intestinal TH17 cell-derived subset can initiate cancer | Nature Immunology nature.com/articles/s4159…

Calling all prospective Immunology PhD Applicants: Apply to SIRPA & get paired with a current student at Stanford Immunology to guide you through the admissions process and provide feedback on your Statement of Purpose! tinyurl.com/apply2sirpa2024

Proud to share early work from my 1st year in the Garcia Lab! 🧬 the tldr: in just a few months, we go from computational design —> real cancer-specific T cell engagers! biorxiv.org/content/10.110…

Day 4 of the AWS Lambda Hackathon No new features but the lads are loving the random split option