Kateryna Tolmachova 🇺🇦
@kattlm
PhD candidate, Bode group, ETH Zürich
ID: 318516351
16-06-2011 16:21:38
153 Tweet
161 Followers
179 Following
So happy to see our UFM1 probes paper out in ACS Central Science! Jakob Farnung and I are big fans of hydrazides, which allow C-terminal protein modification easier than ever. Massive thank you to amosliang, Bode Group, Jacob Corn! pubs.acs.org/doi/10.1021/ac…
NEW #ASAP by Jeffrey Bode & team Bode Group UFM1 activity-based probes were developed via acylation of expressed C-terminal acyl hydrazides with carboxylic anhydrides. Probes showed remarkable selectivity toward UFMylation pathway enzymes go.acs.org/1eR
Sincerely commend EU leaders’ decision at #EUCO to grant 🇺🇦 a candidate status. It’s a unique and historical moment in 🇺🇦-🇪🇺 relations. Grateful to Charles Michel, Ursula von der Leyen and EU leaders for support. Ukraine’s future is within the EU. #EmbraceUkraine
Bode Group adventures in autophagy: We report the presence of an unknown LIR motif in human ATG3 discovered using a combination of new activity-based probes, computational modeling and x-ray crystallography. The LIR motif is crucial for LC3-lipidation. biorxiv.org/content/10.110…
We love it when group members do projects we never expected to be working on...autophagy, protein-structures, CRISPR knockouts. Great work by Jakob Farnung and our collaborators Jacob Corn
This Edge article from Bode Group looks at the installation of electrophiles onto the C-terminus of recombinant ubiquitin and ubiquitin-like proteins! 👏 Sound interesting? You can read the paper in full, for free here🔗 ow.ly/whrS50M9A6C
Very happy to share work from my PhD in the Bode Group. We report the presence of an unknown LIR motif in human ATG3 discovered using a combination of new activity-based probes, modeling and x-ray crystallography. tinyurl.com/mrxtmsv6 ACS Central Science
Semisynthetic LC3 Probes for Autophagy Pathways Reveal a Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic Activity of Human ATG3 NEW #ASAP by Bode Group & co-workers Read it here: go.acs.org/56r
What does it take to degrade a protein? Turns out all you need is a C-terminal amide. In a great collaboration between Jacob Corn and Bode Group we identified C-terminal amides as a degron recognized by SCF/FBXO31. Matthias Muhar Raphael Hofmann