NR4A2 & RGS16 promoters support delivery of cytokines (e.g. IL-12) directly to the tumor site, leading to enhanced antitumor efficacy and long-term survival of mice in both syngeneic and xenogeneic models nature A/Prof Paul Beavis Amanda Chen Emily Derrick nature.com/articles/s4158…

Delighted to share our new approach to enhance CAR T cell function in solid tumours published today nature. In this work we identify a new strategy to generate armoured CAR T cells. nature.com/articles/s4158…

Excited to share that my PhD work is out in nature today! We engineered armoured CAR T cells to express therapeutic payloads only at the tumour site, to improve their safety and efficacy for the treatment of solid cancers. 1/14 nature.com/articles/s4158…

CAR T cells are engineered to drive tumor-restricted expression of proinflammatory cytokines by repurposing endogenous gene regulatory mechanisms nature.com/articles/s4158… #NBThighlight

Pleased to present the latest work from the lab published in Nature Communications in work led by Kevin Sek: nature.com/articles/s4146…

Happy to share a new study led by all-star team Amanda Chen, Kah Min Yap, Imran, Phil Darcy and Prof Paul Beavis showing that tumor site-specific delivery of potent cytokines is a safe way to boost CAR T cell treatment against solid cancers! nature.com/articles/s4158…

Nature research paper: Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery go.nature.com/4le7GMB