New online! Transcriptomics in the era of long-read sequencing bit.ly/3FG0rwU

New preprint from our lab! Why is not everyone working on Transposons? Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons biorxiv.org/content/10.110…

New online! O-GlcNAc transferase is a key regulator of DNA methylation and transposon silencing bit.ly/4hVdLet

🚨 Just out in Science: 2/3 of bacterial gene families have a preferred position on the chromosome—and natural selection put them there! science.org/doi/10.1126/sc… Heinrich-Heine-Universität Düsseldorf CEPLAS

Exciting news! Our latest work in the Nicola Iovino Lab, “Chromatin landscape at cis-regulatory elements orchestrates cell fate decisions in early embryogenesis,” is now published in Nature Communications! nature.com/articles/s4146…

🔥🔥🔥OUR NEW PREPRINT: Slowing and reversing aging? Nature does it, here we show how! Age deceleration and reversal gene patterns in dauer diapause. Huge congrats to Kristy Totska, João Barata, Walter Sandt and David Meyer biorxiv.org/content/10.110…

New Night Science Podcast episode! Martin Schwartz from Yale University talks with us about the importance of stupidity in scientific research, how the ego can obstruct creativity, and how resilience, self-discovery, and the cultivation of "passionate indifference" – are key in science.

DESeq2-MultiBatch: Batch Correction for Multi-Factorial RNA-seq Experiments biorxiv.org/content/10.110… #biorxiv_bioinfo

Nature research paper: Chromatin loops are an ancestral hallmark of the animal regulatory genome go.nature.com/4d1RR8g

(1/n) New preprint from clarice Fan Fang Varshini Ramanathan in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110…

Bonferroni's correction not Tukey's should be used for making pairwise comparisons in experiments with few replicates. biorxiv.org/content/10.110… #biorxiv_bioinfo

Very excited to share our latest work in Molecular Cell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. sciencedirect.com/science/articl…

Epigenetic regulation in early embryo development: from zygotic genome activation to the first lineage specification dlvr.it/TLBnnP

Elusive ORF2p detection with more robust method(s) now

A 4-year postdoc position in population genomics is available in my group at the University of East Anglia, to work on a project sequencing a thousand fox genomes across rural and urban environments in the UK. vacancies.uea.ac.uk/vacancies/1593…

I won't try to summarize everything that happened at "The Woodstock of Biology 2 + Nightscience" (you can see on the other place under this hashtag #TCTeAC) I'll just say that it was an out of body experience, and, in my opinion, historical. #theconferencetoendallconferences

🧵 1/6 — Remembering Barbara McClintock on #TransposonDay (June 16th) Born in 1902, Barbara McClintock revolutionized genetics. Her discovery of transposable elements ("jumping genes") revealed that genomes are not static — but mobile, dynamic, and self-regulating.

I’ve been thinking about form and function a lot recently; conceptualising this in my own work. Chat with Hartl in Prague was rather illuminating. Looking forward to diving into this work ☺️

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease. With such a large scope you need excellent partners, so we are happy to have teamed up with ZZ Zhao Zhang & Vincent Yang Xu nature.com/articles/s4158…

More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…