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In a study published in Nature Nanotechnology, scientists at TU Delft present a new technique to identify proteins. Using this new technology, the researchers can identify individual, intact, full-length proteins, preserving all its information. Read more here👉 edu.nl/63brv

Online Now: Structural atlas of human primary microRNAs generated by SHAPE-MaP dlvr.it/T3fDm1

Watch out, glycoRNA community for the risk! You might be looking at a completely different molecule even following the same isolation procedure. Run the checkpoint experiment to check if it’s glycoRNA! #glycotime biorxiv.org/content/10.110…

Here is our new bioRxiv preprint that studied about critical issues for glycoRNA purification. #glycoRNA #glycotime #RNA_purification N-glycosylated molecules act as a co-precipitant in RNA purification biorxiv.org/content/10.110…

If you have been working or plan to work on #glycoRNA, please spend some #glycotime through this thread, because it is worthwhile knowing the risk you may encounter.

Atomically accurate de novo design of single-domain antibodies biorxiv.org/cgi/content/sh… #bioRxiv

Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle dlvr.it/T5GfWv

It's a great joy to witness the wonderful collaboration and to be a part of it. Thanks to all the groups involved!

RNA-guided RNA silencing by an Asgard archaeal Argonaute Fabai Wu Lab Daan C. Swarts Joo_Lab Carolien Bastiaanssen Pilar B U Kijun Kim @FinocchioGiada #Asgard #archaea #RNAsilencing #Argonaute #evolution nature.com/articles/s4146…

Doctoral degree in the pocket 🥳 Thanks to all committee members for the nice discussions, all collaborators for the cool projects, and Chirlmin and all lab members for the great time in the past few years!

Template-independent enzymatic synthesis of RNA oligonucleotides go.nature.com/3zBfDZf

It’s heparan sulfate again?! In my post-doc research at Joo_Lab , we demonstrate heparan sulfate acts as scaffold to present RNA and RBP on cell surface. The three biomolecules work together to modulate cell-surface receptor-ligand interaction. biorxiv.org/content/10.110…

Happy to share our exciting findings on cell surface RNA. Heparan sulfate acts as a scaffold for RNA & RBPs to orchestrate receptor-ligand interactions. I was fortunate to be part of Joo_Lab to carry out this work as part of my postdoc research. biorxiv.org/content/10.110…

After years of development, we proudly present SPARXS in @sciencemagazine. By combining single-molecule fluorescence microscopy with next-generation sequencing, large sequence libraries can now be studied at the single-molecule level! science.org/doi/10.1126/sc…

🧬Examining DNA molecules was a slow process. Biophysicists developed a technique that speeds up screening of individual DNA molecules at least a thousand times. They can measure millions of DNA molecules within a week instead of years to decades. 👉edu.nl/pqf3x

The structural landscape of Microprocessor-mediated processing of pri-... sciencedirect.com/science/articl… Ankur Garg's beautiful work on how the Microprocessor tackles the diversity of pri-miRNAs is out! Thanks also to Renfu Shang, Todor Cvetanovic and eric lai! Cold Spring Harbor Laboratory @HHMI

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Do you want to perform single-molecule fluorescence measurements of thousands of different sequences in one go? Good news, our detailed protocol for SPARXS is now out in Nature Protocols! nature.com/articles/s4159…