1/n Looking into history of "fragile nucleosomes". The term was introduced in Xi et al, 2011 genome.cshlp.org/content/21/5/7……. But before that, MNase-sensitive nucleosomes were known as "labile nucleosomes", since 1970s academic.oup.com/nar/article/6/…. This term then continued into the NGS era

Starting in 4 hours - register and join us! FragileNucleosome EpiCypher, Inc.

📢 calling prospective postdocs! Only a few days left to apply to join our growing group in the beautiful city of Edinburgh to lead an exciting project focused on how gene expression, RNA metabolism and cell signalling are all coordinated with changes in cell size.

1/4 Our bioRxiv, 'Origin of Ewing Sarcoma by Embryonic Reprogramming of Neural Crest to Mesoderm' is now available on bioRxiv! In this study, we explore the enigmatic origin of Ewing sarcoma using our zebrafish genetic cancer models. We revealed that neural crest cells

I am thrilled to start today Caltech and looking forward to the exciting science ahead.

Our new study, initiated by an undergraduate in the lab, was set to examine the effect of mutating histone H3.3 K122 to alanine. To do so, we attempted to generate murine ES cells mutating all four alleles, but were surprised when we couldn't generate these lines!

📢Postdoc available! We are looking for curious minds to answer big questions using epigenome editing Join us at EMBL Rome - we offer training, supportive environment, top salary and scientific excellence. Also - sun, culture & Italian food😉 Info+apply: embl.org/jobs/position/…

Join us tomorrow!

Coming up in about 4 hours! Join us for talks from Dr Alex Payne-Dwyer, Wilson Nartey, and Xiukun Wang. Register here: us06web.zoom.us/webinar/regist…

A big new batch of our FragileNucleosome seminar videos have gone public in the past couple weeks! Here's a thread 1/9

Why did nature choose Dnmt3b? Komal Yasmin tells us about her work that's now on bioRxiv: biorxiv.org/content/10.110…, youtu.be/u2e0P3j1eHk

Latest research from the Teves lab is now out on Biorxiv! "Functional divergence of TBP homologs through distinct DNA binding dynamics" biorxiv.org/content/10.110… Here, we examine how conservation is balanced with diversification throughout evolution, using TBP as a case study.

In ~3 hours...

It has finally arrived: The first book written, and sold, in DNA. Thanks @catalogtechinc and Imagene for making this happen! Pre-orders are still open. If you order a capsule, we also send you a physical book. And those are cool, too. Links here: press.asimov.com/books

🚨Postdoc and Postbac positions available in my group at the @NIEHS /NIH ! Interested in investigating the neural mechanisms for social behaviors across development in a supportive environment? Make sure to apply! Job ads in🧵Feel free to DM/email w/ questions, please RT

Hey friends, you should sign up to give a talk to the FragileNucleosome community this year!

I'm super happy to now be able to share the published version of our paper at Science Advances showing that: 1) active histone mods occur independently of transcription 2) transcription coordinates histone deacetylation at active promoters science.org/doi/10.1126/sc…