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Excited to share our work on TAPIR, a generalizable ML model that can predict TCR-target interaction! T-cell receptors (TCRs) are involved in most diseases, but linking their sequences with targets is an unsolved grand challenge in the field. biorxiv.org/content/10.110…

Among hospitalized adults, the risk of acute kidney injury did not differ between cefepime and piperacillin-tazobactam, but neurological dysfunction was more common with cefepime. #IDWeek2023 ja.ma/3RYQHSD

Watch out anesthesia. Neurosurgery is coming for your ET tubes

I’m happy to share that Haney lab at UPenn is now open: haneylab.org. I'm very excited to be a part of Penn Path & Lab Medicine and Institute on Aging! Reach out if you’re interested in brain aging, microglia, neuroimmunology, and functional genomics. We’re hiring at all levels.

Fascinating discovery by ⁦Stanford Medicine⁩ MSTP alum ⁦John Pluvinage⁩ out in ⁦Science Translational Medicine⁩ Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency | Science Translational Medicine science.org/doi/10.1126/sc…

Studying a patient with neurological deficits, scientists discovered autoantibodies against the #transcobalamin receptor CD320 that lead to #VitaminB12 deficiency in the central nervous system, but not in the blood. John Pluvinage UC San Francisco scim.ag/7wN

In new Science Translational Medicine paper, UC San Francisco team (including #CZBiohubSF president Joe DeRisi) cracks a medical mystery--and reveals some fascinating human biology in the bargain! 🤯 Read more ⤵️

V cool molecular mimicry

Amazing resource

In silico prediction -> function -> structure -> in vivo efficacy. Cool #glycotime. Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologies: Cell cell.com/cell/fulltext/…

Striking finding, elegantly investigated-congrats!

Our meta-analysis comparing intracranial hemorrhage risks w/ ASA vs apix, now online @ Stroke. Contrary to common perceptions, we found no evidence in the ischemic stroke prevention setting that apix confers higher intracranial bleeding risk vs ASA. ahajournals.org/doi/10.1161/ST…