
Julia Anna Ruehle
@juruehle
ID: 1483067237753835522
17-01-2022 13:24:18
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77 Followers
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Shoutout to my fantastic PhD colleague Robert Frömel for his work on screening thousands of synthetic enhancers in differentiating primary cells. Glad to be part of it 😊


🧬How can enhancers achieve tissue-specific activity? We use MPRAs of synthetic enhancers to derive interpretable rules on TFBS arrangement🚦and discover that negative synergies drive specificity in hematopoiesis. Shoutout to Robert Frömel & @larsplus for leading this work🦹