#SimPub #CircESC2024 Lifelong LDL-C levels, driven by rare genetic variants, significantly influence aortic stenosis (AS) risk. Findings suggest that early & sustained lipid-lowering therapy could be key in preventing AS. ahajournals.org/doi/10.1161/CI…

Is LDL-C a causal risk factor for aortic stenosis? We're excited to see our study now in Circulation examining this question by leveraging rare protein-disrupting variants in UK Biobank and AllofUsResearch. With Sean Jurgens, Shino Kany, Patrick Ellinor & James 🥥🏈 Pirruccello.

Prevention requires bold & forward-thinking investments. My OpEd on why letting funding lapse for AllofUsResearch would be a step backwards statnews.com/2024/09/03/all… STAT

James R. Priest MD Aeron Small Sean Jurgens Shino Kany Patrick Ellinor I think it is just teaching us that there are distinct biological processes underpinning ascending aortic aneurysm and aortic valve stenosis.