Solid #tumours have largely been resistant to CAR T #celltherapy due to an immunosuppressive microenvironment 🛑 This review discusses new strategies being developed to deliver vital co-stimulatory signals to CAR #Tcells 👉buff.ly/3rOaEwr 👏 Clare Slaney Peter Mac Research

Featured this month is a review from Felix Marsh-Wakefield et al on the use of high‐dimensional cytometry in #immunology research. Data from these experiments are often under‐utilised. Are you making the most of YOUR data? Thomas Ashhurst Helen McGuire #BigData #ICBnews onlinelibrary.wiley.com/doi/10.1111/im…

Not only IFNG is mediated through AU-rich elements, other immune mediators are also heavily ARE-regulated! New Nature Communications paper looks at how malaria inhibits monocyte CXCL10 production by exploiting AREs. Biology + co-evolution never cease to amaze me! nature.com/articles/s4146…

I didn't know this: 'THERE IS NO SUCH THING AS A C57BL/6 MOUSE!' jax.org/news-and-insig…

Great new work from Sanquin by Loreto Parga Vidal and Felix Behr from the van Gisbergen group about the roles of Hobit and Eomes in Trm formation through lineage tracing!

More cool work from the Sanquin van Gisbergen lab in collaboration with Georg Gasteiger, where Renske Taggenbrock and Christin Friedrich investigated the role of Hobit in murine ILC1s across tissues. #hobit #ILC #immunology

We're #hiring! Looking for a fun technician position doing research for #pharma & #biotech? Interested in executing cellular assays in (pre)clinical phase? Come be my colleague and join Sanquin Immunomonitoring Services! Apply here: sanquin.org/nl/werken-bij/… RT = appreciated

Super excited to share our latest manuscript that is now online bioRxiv. We identified RNA binding proteins that interact with cytokine mRNAs and that are critical for fine-tuning of cytokine production in human T cells. @WolkersMonika biorxiv.org/content/10.110…

Hobit and Blimp-1 instruct the differentiation of iNKT cells into resident-phenotype lymphocytes after lineage commitment Kragten, Taggenbrock, Parga Vidal, van Lier, Stark, van Gisbergen Amsterdam UMC bit.ly/3q7tRJD

We're #hiring for a Scientist MHC Biology Sanquin, see sanquin.org/nl/werken-bij/… or contact me for more details.

Know any immunologists who gave you really good career advice? Drop me a line so I can try to get them to communicate that advice further. ICB - the journal, the society #immunology journal from Australian and New Zealand Society for Immunology has a really exciting project incubating...

Flow cytometry is not just for looking at protein, but works like a charm (sometimes) to measure specific RNAs too! Read about how I think it could be a useful tool in #EBV #research here in ISAC's Cytometry A (a Wiley journal): doi.org/10.1002/cyto.a…

Creating new tools to study emerging virusses is always a race against the clock. Read more about how FISH and Flow-FISH have helped in the fight against SARS-COV-2 in my Letter to the Editor of ISAC's Cytometry Part A here: doi.org/10.1002/cyto.a…

#ImmunologyFutures advice on "saying no to academic service"! ICB - the journal! onlinelibrary.wiley.com/doi/10.1111/im… Thanks @DamiMasMenos Julian Freen-van Heeren, PhD. @kswilcox Nik Joshi @LM_Ince Andrea Hicks @FitzFitzsimons Joanna Groom Science Sophie Professor John Tregoning Alerie Guzman de la Fuente Annabelle Singer et al for 🧠

Happy to share our latest publication in ICB - the journal, where we elaborate on the recent beautiful Masopust Vezys Lab paper on T cell longevity. Read about it here: onlinelibrary.wiley.com/doi/abs/10.111…

A one-stop tool screen targets in human T cells for enhanced functionality and redirect antigen specificity at the same time with CRISPR? Cool! Read our recent commentary on a Nature Biotechnology paper in The CRISPR Journal below!

Happy to share a News & Views I recently wrote for Journal of Leukocyte Biology! It explores the findings of a recent PNASNews article by Guo et al. about gamma delta T cell polyspecificity. You can read it here: doi.org/10.1093/jleuko…

Happy to have been able to play a small part in finishing this interesting project by examining in vitro MHC:peptide interactions! #melanoma #forlife

Combining VPD450 dye dilution and EdU incorporation provides additional insights into T cell proliferation kinetics. Applications include assessing novel vaccine efficiency and designing new treatments targeting T cell proliferation. onlinelibrary.wiley.com/doi/10.1111/im…

Excited to share our recent publication in ICB - the journal. What started as a student project in our group turned into a full-fledged technique that simultaneously assesses short- and long-term T cell proliferation in the same cell via flow cytometry. #FACS #Immunology